Transcription-coupled repair and premature ageing

J. O. Andressoo; J. H.J. Hoeijmakers

doi:10.1016/j.mrfmmm.2005.04.004

Transcription-coupled repair and premature ageing

J. O. Andressoo
, J. H.J. Hoeijmakers

Research output: Contribution to journal › Review article › peer-review

63 Citations (Scopus)

Abstract

During the past decades, several cellular pathways have been discovered to be connected with the ageing process. These pathways, which either suppress or enhance the ageing process, include regulation of the insulin/growth hormone axis, pathways involved with caloric restriction, ROS metabolism and DNA repair. In this review, we will provide a comprehensive overview of cancer and/or accelerated ageing pathologies associated with defects in the multi-step nucleotide excision repair pathway. Moreover, we will discuss evidence suggesting that there is a causative link between transcription-coupled repair and ageing.

Original language	English
Pages (from-to)	179-194
Number of pages	16
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	577
Issue number	1-2 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.mrfmmm.2005.04.004
Publication status	Published - 4 Sept 2005
Externally published	Yes

Keywords

Biology of ageing
NER-associated disease
Transcription-coupled repair

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10.1016/j.mrfmmm.2005.04.004

Cite this

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title = "Transcription-coupled repair and premature ageing",

abstract = "During the past decades, several cellular pathways have been discovered to be connected with the ageing process. These pathways, which either suppress or enhance the ageing process, include regulation of the insulin/growth hormone axis, pathways involved with caloric restriction, ROS metabolism and DNA repair. In this review, we will provide a comprehensive overview of cancer and/or accelerated ageing pathologies associated with defects in the multi-step nucleotide excision repair pathway. Moreover, we will discuss evidence suggesting that there is a causative link between transcription-coupled repair and ageing.",

keywords = "Biology of ageing, NER-associated disease, Transcription-coupled repair",

author = "Andressoo, \{J. O.\} and Hoeijmakers, \{J. H.J.\}",

note = "Funding Information: Special thanks to N.G.J. Jaspers, J. Mitchell, G. Garinis and S. Bergink for helpful discussions. This work was financially supported by the Netherlands Organization for Scientific Research (NWO) through the foundation of the Research Institute Diseases of the Elderly, as well as grants from the NIH (1PO1 AG17242-02), NIEHS (1UO1 ES011044), EC (QRTL-1999-02002), and the Dutch Cancer Society (EUR 99-2004).",

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doi = "10.1016/j.mrfmmm.2005.04.004",

language = "English",

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AU - Andressoo, J. O.

AU - Hoeijmakers, J. H.J.

N1 - Funding Information: Special thanks to N.G.J. Jaspers, J. Mitchell, G. Garinis and S. Bergink for helpful discussions. This work was financially supported by the Netherlands Organization for Scientific Research (NWO) through the foundation of the Research Institute Diseases of the Elderly, as well as grants from the NIH (1PO1 AG17242-02), NIEHS (1UO1 ES011044), EC (QRTL-1999-02002), and the Dutch Cancer Society (EUR 99-2004).

PY - 2005/9/4

Y1 - 2005/9/4

N2 - During the past decades, several cellular pathways have been discovered to be connected with the ageing process. These pathways, which either suppress or enhance the ageing process, include regulation of the insulin/growth hormone axis, pathways involved with caloric restriction, ROS metabolism and DNA repair. In this review, we will provide a comprehensive overview of cancer and/or accelerated ageing pathologies associated with defects in the multi-step nucleotide excision repair pathway. Moreover, we will discuss evidence suggesting that there is a causative link between transcription-coupled repair and ageing.

AB - During the past decades, several cellular pathways have been discovered to be connected with the ageing process. These pathways, which either suppress or enhance the ageing process, include regulation of the insulin/growth hormone axis, pathways involved with caloric restriction, ROS metabolism and DNA repair. In this review, we will provide a comprehensive overview of cancer and/or accelerated ageing pathologies associated with defects in the multi-step nucleotide excision repair pathway. Moreover, we will discuss evidence suggesting that there is a causative link between transcription-coupled repair and ageing.

KW - Biology of ageing

KW - NER-associated disease

KW - Transcription-coupled repair

UR - https://www.scopus.com/pages/publications/24044532209

U2 - 10.1016/j.mrfmmm.2005.04.004

DO - 10.1016/j.mrfmmm.2005.04.004

M3 - Review article

C2 - 16009385

AN - SCOPUS:24044532209

SN - 0027-5107

VL - 577

SP - 179

EP - 194

JO - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

JF - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

IS - 1-2 SPEC. ISS.

ER -

Transcription-coupled repair and premature ageing

Abstract

Keywords

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