Transcriptional control of lymphoid development: Lessons from gene targeting

Hans C. Clevers; Rudolf Grosschedl

doi:10.1016/0167-5699(96)10019-0

Transcriptional control of lymphoid development: Lessons from gene targeting

Hans C. Clevers, Rudolf Grosschedl

Research output: Contribution to journal › Review article › peer-review

91 Citations (Scopus)

Abstract

Cis-acting control regions have been defined for many hematopoietic genes and used to identify DNA-binding factors. The orderly expression of these factors is hypothesized to control entry into and progression along the various differentiation pathways. Gene-knockout technology is now unveiling the essential functions of these candidate differentiation control factors. Here, Hans Clevers and Rudolf Grosschedl discuss the results and implications of a number of such gene-disruption experiments.

Original language	English
Pages (from-to)	336-343
Number of pages	8
Journal	Immunology Today
Volume	17
Issue number	7
DOIs	https://doi.org/10.1016/0167-5699(96)10019-0
Publication status	Published - Jul 1996
Externally published	Yes

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title = "Transcriptional control of lymphoid development: Lessons from gene targeting",

abstract = "Cis-acting control regions have been defined for many hematopoietic genes and used to identify DNA-binding factors. The orderly expression of these factors is hypothesized to control entry into and progression along the various differentiation pathways. Gene-knockout technology is now unveiling the essential functions of these candidate differentiation control factors. Here, Hans Clevers and Rudolf Grosschedl discuss the results and implications of a number of such gene-disruption experiments.",

author = "Clevers, {Hans C.} and Rudolf Grosschedl",

note = "Funding Information: The authors wish to thank the memberso f the Clevers and Grosschedll abs for helpful comments,a nd I. Janssen for artwork. H.C. is supported by a PIONIER grant from NWO. R.G. is supported by the Howard Hughes Medical Institute.",

year = "1996",

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doi = "10.1016/0167-5699(96)10019-0",

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journal = "Immunology Today",

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T1 - Transcriptional control of lymphoid development

T2 - Lessons from gene targeting

AU - Clevers, Hans C.

AU - Grosschedl, Rudolf

N1 - Funding Information: The authors wish to thank the memberso f the Clevers and Grosschedll abs for helpful comments,a nd I. Janssen for artwork. H.C. is supported by a PIONIER grant from NWO. R.G. is supported by the Howard Hughes Medical Institute.

PY - 1996/7

Y1 - 1996/7

N2 - Cis-acting control regions have been defined for many hematopoietic genes and used to identify DNA-binding factors. The orderly expression of these factors is hypothesized to control entry into and progression along the various differentiation pathways. Gene-knockout technology is now unveiling the essential functions of these candidate differentiation control factors. Here, Hans Clevers and Rudolf Grosschedl discuss the results and implications of a number of such gene-disruption experiments.

AB - Cis-acting control regions have been defined for many hematopoietic genes and used to identify DNA-binding factors. The orderly expression of these factors is hypothesized to control entry into and progression along the various differentiation pathways. Gene-knockout technology is now unveiling the essential functions of these candidate differentiation control factors. Here, Hans Clevers and Rudolf Grosschedl discuss the results and implications of a number of such gene-disruption experiments.

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U2 - 10.1016/0167-5699(96)10019-0

DO - 10.1016/0167-5699(96)10019-0

M3 - Review article

C2 - 8763820

AN - SCOPUS:0029954710

SN - 0167-5699

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SP - 336

EP - 343

JO - Immunology Today

JF - Immunology Today

IS - 7

ER -

Transcriptional control of lymphoid development: Lessons from gene targeting

Abstract

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