Transformation locked in a loop

Jarno Drost; Reuven Agami

doi:10.1016/j.cell.2009.10.035

Transformation locked in a loop

Jarno Drost, Reuven Agami

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

During neoplastic transformation, cells can promote their own growth by activating proto-oncogenes. Reporting in Cell, Iliopoulos et al. (2009) now show that in certain cell types, a transient oncogenic signal is sufficient to induce neoplastic transformation and to maintain it through a positive feedback loop driven by the inflammatory cytokine interleukin-6.

Original language	English
Pages (from-to)	654-6
Number of pages	3
Journal	Cell
Volume	139
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2009.10.035
Publication status	Published - 13 Nov 2009
Externally published	Yes

Keywords

Cell Transformation, Neoplastic
Feedback, Physiological
Humans
Inflammation
Interleukin-6/metabolism

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10.1016/j.cell.2009.10.035

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@article{328a06632ddd47a1885b9a206087c369,

title = "Transformation locked in a loop",

abstract = "During neoplastic transformation, cells can promote their own growth by activating proto-oncogenes. Reporting in Cell, Iliopoulos et al. (2009) now show that in certain cell types, a transient oncogenic signal is sufficient to induce neoplastic transformation and to maintain it through a positive feedback loop driven by the inflammatory cytokine interleukin-6.",

keywords = "Cell Transformation, Neoplastic, Feedback, Physiological, Humans, Inflammation, Interleukin-6/metabolism",

author = "Jarno Drost and Reuven Agami",

year = "2009",

month = nov,

day = "13",

doi = "10.1016/j.cell.2009.10.035",

language = "English",

volume = "139",

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journal = "Cell",

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TY - JOUR

T1 - Transformation locked in a loop

AU - Drost, Jarno

AU - Agami, Reuven

PY - 2009/11/13

Y1 - 2009/11/13

N2 - During neoplastic transformation, cells can promote their own growth by activating proto-oncogenes. Reporting in Cell, Iliopoulos et al. (2009) now show that in certain cell types, a transient oncogenic signal is sufficient to induce neoplastic transformation and to maintain it through a positive feedback loop driven by the inflammatory cytokine interleukin-6.

AB - During neoplastic transformation, cells can promote their own growth by activating proto-oncogenes. Reporting in Cell, Iliopoulos et al. (2009) now show that in certain cell types, a transient oncogenic signal is sufficient to induce neoplastic transformation and to maintain it through a positive feedback loop driven by the inflammatory cytokine interleukin-6.

KW - Cell Transformation, Neoplastic

KW - Feedback, Physiological

KW - Humans

KW - Inflammation

KW - Interleukin-6/metabolism

UR - https://www.scopus.com/pages/publications/70350784147

U2 - 10.1016/j.cell.2009.10.035

DO - 10.1016/j.cell.2009.10.035

M3 - Article

C2 - 19914159

SN - 0092-8674

VL - 139

SP - 654

EP - 656

JO - Cell

JF - Cell

IS - 4

ER -

Transformation locked in a loop

Abstract

Keywords

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