Abstract
Transforming growth factor beta (TGF-β) is a hormonally regulated growth inhibitor with autocrine and/or paracrine functions in human breast cancer. In vivo, enhanced immunohistochemical staining of extracellular TGF-β1 has been detected around stromal fibroblasts in response to the antiestrogen treatment. We have investigated the effects of tamoxifen on the production of TGF-β by primary human breast fibroblast cultures in serum-free medium. Highly variable levels of mainly latent TGF-β1 were detected in conditioned media from both tumor and normal tissue derived fibroblasts. Hydroxy-tamoxifen was shown to increase latent TGF-β1 secretion in three of the eight tumor tissue-derived fibroblast cultures. Such effect of hydroxy-tamoxifen was not observed in fibroblast cultures established from normal adjacent breast tissue.
Original language | English |
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Pages (from-to) | 1-6 |
Number of pages | 6 |
Journal | Molecular and Cellular Endocrinology |
Volume | 111 |
Issue number | 1 |
DOIs | |
Publication status | Published - 28 Apr 1995 |
Externally published | Yes |
Keywords
- Fibroblast
- Human breast cells
- Tamoxifen
- Transforming growth factor-beta