Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia

Siroon Bekkering, Lotte C.A. Stiekema, Sophie Bernelot Moens, Simone L. Verweij, Boris Novakovic, Koen Prange, Miranda Versloot, Jeanine E. Roeters van Lennep, Henk Stunnenberg, Menno de Winther, Erik S.G. Stroes, Leo A.B. Joosten, Mihai G. Netea, Niels P. Riksen

Research output: Contribution to journalLetterpeer-review

90 Citations (Scopus)

Abstract

Individuals with elevated LDL-cholesterol levels have an increased risk for cardiovascular disease. Despite lipid lowering strategies, however, a significant cardiovascular risk remains. Bekkering et al. show that monocytes from patients with familial hypercholesterolemia have a trained immunity phenotype and that lipid lowering with statins does not revert this pro-inflammatory phenotype.

Original languageEnglish
Pages (from-to)1-2
Number of pages2
JournalCell Metabolism
Volume30
Issue number1
DOIs
Publication statusPublished - 2 Jul 2019
Externally publishedYes

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