Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia

Siroon Bekkering; Lotte C.A. Stiekema; Sophie Bernelot Moens; Simone L. Verweij; Boris Novakovic; Koen Prange; Miranda Versloot; Jeanine E. Roeters van Lennep; Henk Stunnenberg; Menno de Winther; Erik S.G. Stroes; Leo A.B. Joosten; Mihai G. Netea; Niels P. Riksen

doi:10.1016/j.cmet.2019.05.014

Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia

Siroon Bekkering
, Lotte C.A. Stiekema
, Sophie Bernelot Moens
, Simone L. Verweij
, Boris Novakovic
, Koen Prange
, Miranda Versloot
, Jeanine E. Roeters van Lennep
, Henk Stunnenberg
, Menno de Winther
, Erik S.G. Stroes
, Leo A.B. Joosten
, Mihai G. Netea
, Niels P. Riksen

Research output: Contribution to journal › Letter › peer-review

128 Citations (Scopus)

Abstract

Individuals with elevated LDL-cholesterol levels have an increased risk for cardiovascular disease. Despite lipid lowering strategies, however, a significant cardiovascular risk remains. Bekkering et al. show that monocytes from patients with familial hypercholesterolemia have a trained immunity phenotype and that lipid lowering with statins does not revert this pro-inflammatory phenotype.

Original language	English
Pages (from-to)	1-2
Number of pages	2
Journal	Cell Metabolism
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2019.05.014
Publication status	Published - 2 Jul 2019
Externally published	Yes

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10.1016/j.cmet.2019.05.014

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Bekkering, S., Stiekema, L. C. A., Bernelot Moens, S., Verweij, S. L., Novakovic, B., Prange, K., Versloot, M., Roeters van Lennep, J. E., Stunnenberg, H., de Winther, M., Stroes, E. S. G., Joosten, L. A. B., Netea, M. G., & Riksen, N. P. (2019). Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia. Cell Metabolism, 30(1), 1-2. https://doi.org/10.1016/j.cmet.2019.05.014

@article{49a3071f41ba4aa187e8c45ef407d464,

title = "Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia",

abstract = "Individuals with elevated LDL-cholesterol levels have an increased risk for cardiovascular disease. Despite lipid lowering strategies, however, a significant cardiovascular risk remains. Bekkering et al. show that monocytes from patients with familial hypercholesterolemia have a trained immunity phenotype and that lipid lowering with statins does not revert this pro-inflammatory phenotype.",

author = "Siroon Bekkering and Stiekema, \{Lotte C.A.\} and \{Bernelot Moens\}, Sophie and Verweij, \{Simone L.\} and Boris Novakovic and Koen Prange and Miranda Versloot and \{Roeters van Lennep\}, \{Jeanine E.\} and Henk Stunnenberg and \{de Winther\}, Menno and Stroes, \{Erik S.G.\} and Joosten, \{Leo A.B.\} and Netea, \{Mihai G.\} and Riksen, \{Niels P.\}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = jul,

day = "2",

doi = "10.1016/j.cmet.2019.05.014",

language = "English",

volume = "30",

pages = "1--2",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Cell Press",

number = "1",

}

Bekkering, S, Stiekema, LCA, Bernelot Moens, S, Verweij, SL, Novakovic, B, Prange, K, Versloot, M, Roeters van Lennep, JE, Stunnenberg, H, de Winther, M, Stroes, ESG, Joosten, LAB, Netea, MG & Riksen, NP 2019, 'Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia', Cell Metabolism, vol. 30, no. 1, pp. 1-2. https://doi.org/10.1016/j.cmet.2019.05.014

TY - JOUR

T1 - Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia

AU - Bekkering, Siroon

AU - Stiekema, Lotte C.A.

AU - Bernelot Moens, Sophie

AU - Verweij, Simone L.

AU - Novakovic, Boris

AU - Prange, Koen

AU - Versloot, Miranda

AU - Roeters van Lennep, Jeanine E.

AU - Stunnenberg, Henk

AU - de Winther, Menno

AU - Stroes, Erik S.G.

AU - Joosten, Leo A.B.

AU - Netea, Mihai G.

AU - Riksen, Niels P.

PY - 2019/7/2

Y1 - 2019/7/2

N2 - Individuals with elevated LDL-cholesterol levels have an increased risk for cardiovascular disease. Despite lipid lowering strategies, however, a significant cardiovascular risk remains. Bekkering et al. show that monocytes from patients with familial hypercholesterolemia have a trained immunity phenotype and that lipid lowering with statins does not revert this pro-inflammatory phenotype.

AB - Individuals with elevated LDL-cholesterol levels have an increased risk for cardiovascular disease. Despite lipid lowering strategies, however, a significant cardiovascular risk remains. Bekkering et al. show that monocytes from patients with familial hypercholesterolemia have a trained immunity phenotype and that lipid lowering with statins does not revert this pro-inflammatory phenotype.

UR - https://www.scopus.com/pages/publications/85067859614

U2 - 10.1016/j.cmet.2019.05.014

DO - 10.1016/j.cmet.2019.05.014

M3 - Letter

C2 - 31204280

AN - SCOPUS:85067859614

SN - 1550-4131

VL - 30

SP - 1

EP - 2

JO - Cell Metabolism

JF - Cell Metabolism

IS - 1

ER -

Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia

Abstract

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