Tumor suppressors BTG1 and BTG2: Beyond growth control

Laurensia Yuniati, Blanca Scheijen, Laurens T van der Meer, Frank N van Leeuwen

Research output: Contribution to journalReview articlepeer-review

98 Citations (Scopus)

Abstract

Since the identification of B-cell translocation gene 1 (BTG1) and BTG2 as antiproliferation genes more than two decades ago, their protein products have been implicated in a variety of cellular processes including cell division, DNA repair, transcriptional regulation and messenger RNA stability. In addition to affecting differentiation during development and in the adult, BTG proteins play an important role in maintaining homeostasis under conditions of cellular stress. Genomic profiling of B-cell leukemia and lymphoma has put BTG1 and BTG2 in the spotlight, since both genes are frequently deleted or mutated in these malignancies, pointing towards a role as tumor suppressors. Moreover, in solid tumors, reduced expression of BTG1 or BTG2 is often correlated with malignant cell behavior and poor treatment outcome. Recent studies have uncovered novel roles for BTG1 and BTG2 in genotoxic and integrated stress responses, as well as during hematopoiesis. This review summarizes what is currently known about the roles of BTG1 and BTG2 in these and other cellular processes. In addition, we will highlight the molecular mechanisms and biological consequences of BTG1 and BTG2 deregulation during cancer progression and elaborate on the potential clinical implications of these findings.

Original languageEnglish
Pages (from-to)5379-5389
Number of pages11
JournalJournal of Cellular Physiology
Volume234
Issue number5
DOIs
Publication statusPublished - May 2019
Externally publishedYes

Keywords

  • Animals
  • Cell Cycle
  • Cell Differentiation
  • Cell Proliferation
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Immediate-Early Proteins/genetics
  • Neoplasm Proteins/genetics
  • Neoplasms/genetics
  • Signal Transduction
  • Transcription, Genetic
  • Tumor Suppressor Proteins/genetics

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