Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion

J. H.W. De Wilt; T. L.M. Ten Hagen; G. De Boeck; S. T. Van Tiel; E. A. De Bruijn; A. M.M. Eggermont

doi:10.1054/bjoc.1999.1032

Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion

J. H.W. De Wilt, T. L.M. Ten Hagen, G. De Boeck, S. T. Van Tiel, E. A. De Bruijn, A. M.M. Eggermont

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Abstract

Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-α) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant sixfold increase in melphalan tumour tissue concentration after ILP when TNF-α was added to the perfusate, which provides a straightforward explanation for the observed synergism between melphalan and TNF-α in ILP. (C) 2000 Cancer Research Campaign.

Original language	English
Pages (from-to)	1000-1003
Number of pages	4
Journal	British Journal of Cancer
Volume	82
Issue number	5
DOIs	https://doi.org/10.1054/bjoc.1999.1032
Publication status	Published - 2000
Externally published	Yes

Keywords

Isolated limb perfusion
Melphalan
Rats
Tissue concentration
TNF

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10.1054/bjoc.1999.1032

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title = "Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion",

abstract = "Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-α) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant sixfold increase in melphalan tumour tissue concentration after ILP when TNF-α was added to the perfusate, which provides a straightforward explanation for the observed synergism between melphalan and TNF-α in ILP. (C) 2000 Cancer Research Campaign.",

keywords = "Isolated limb perfusion, Melphalan, Rats, Tissue concentration, TNF",

author = "{De Wilt}, {J. H.W.} and {Ten Hagen}, {T. L.M.} and {De Boeck}, G. and {Van Tiel}, {S. T.} and {De Bruijn}, {E. A.} and Eggermont, {A. M.M.}",

note = "Funding Information: This work was financed in part by a grant from the Dutch Cancer Society. Boehringer Ingelheim GmbH is acknowledged for generously providing TNF-a .",

year = "2000",

doi = "10.1054/bjoc.1999.1032",

language = "English",

volume = "82",

pages = "1000--1003",

journal = "British Journal of Cancer",

issn = "0007-0920",

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TY - JOUR

T1 - Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion

AU - De Wilt, J. H.W.

AU - Ten Hagen, T. L.M.

AU - De Boeck, G.

AU - Van Tiel, S. T.

AU - De Bruijn, E. A.

AU - Eggermont, A. M.M.

N1 - Funding Information: This work was financed in part by a grant from the Dutch Cancer Society. Boehringer Ingelheim GmbH is acknowledged for generously providing TNF-a .

PY - 2000

Y1 - 2000

N2 - Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-α) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant sixfold increase in melphalan tumour tissue concentration after ILP when TNF-α was added to the perfusate, which provides a straightforward explanation for the observed synergism between melphalan and TNF-α in ILP. (C) 2000 Cancer Research Campaign.

AB - Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-α) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant sixfold increase in melphalan tumour tissue concentration after ILP when TNF-α was added to the perfusate, which provides a straightforward explanation for the observed synergism between melphalan and TNF-α in ILP. (C) 2000 Cancer Research Campaign.

KW - Isolated limb perfusion

KW - Melphalan

KW - Rats

KW - Tissue concentration

KW - TNF

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U2 - 10.1054/bjoc.1999.1032

DO - 10.1054/bjoc.1999.1032

M3 - Article

C2 - 10737379

AN - SCOPUS:0034012752

SN - 0007-0920

VL - 82

SP - 1000

EP - 1003

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 5

ER -

Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion

Abstract

Keywords

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