Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion

J. H.W. De Wilt; T. L.M. Ten Hagen; G. De Boeck; S. T. Van Tiel; E. A. De Bruijn; A. M.M. Eggermont

doi:10.1054/bjoc.1999.1032

Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion

J. H.W. De Wilt
, T. L.M. Ten Hagen
, G. De Boeck
, S. T. Van Tiel
, E. A. De Bruijn
, A. M.M. Eggermont

Research output: Contribution to journal › Article › peer-review

182 Citations (Scopus)

Abstract

Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-α) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant sixfold increase in melphalan tumour tissue concentration after ILP when TNF-α was added to the perfusate, which provides a straightforward explanation for the observed synergism between melphalan and TNF-α in ILP. (C) 2000 Cancer Research Campaign.

Original language	English
Pages (from-to)	1000-1003
Number of pages	4
Journal	British journal of cancer
Volume	82
Issue number	5
DOIs	https://doi.org/10.1054/bjoc.1999.1032
Publication status	Published - 2000
Externally published	Yes

Keywords

Isolated limb perfusion
Melphalan
Rats
TNF
Tissue concentration

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10.1054/bjoc.1999.1032

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title = "Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion",

abstract = "Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-α) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant sixfold increase in melphalan tumour tissue concentration after ILP when TNF-α was added to the perfusate, which provides a straightforward explanation for the observed synergism between melphalan and TNF-α in ILP. (C) 2000 Cancer Research Campaign.",

keywords = "Isolated limb perfusion, Melphalan, Rats, TNF, Tissue concentration",

author = "\{De Wilt\}, \{J. H.W.\} and \{Ten Hagen\}, \{T. L.M.\} and \{De Boeck\}, G. and \{Van Tiel\}, \{S. T.\} and \{De Bruijn\}, \{E. A.\} and Eggermont, \{A. M.M.\}",

note = "Funding Information: This work was financed in part by a grant from the Dutch Cancer Society. Boehringer Ingelheim GmbH is acknowledged for generously providing TNF-a .",

year = "2000",

doi = "10.1054/bjoc.1999.1032",

language = "English",

volume = "82",

pages = "1000--1003",

journal = "British journal of cancer",

issn = "0007-0920",

publisher = "Springer Nature",

number = "5",

}

TY - JOUR

T1 - Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion

AU - De Wilt, J. H.W.

AU - Ten Hagen, T. L.M.

AU - De Boeck, G.

AU - Van Tiel, S. T.

AU - De Bruijn, E. A.

AU - Eggermont, A. M.M.

N1 - Funding Information: This work was financed in part by a grant from the Dutch Cancer Society. Boehringer Ingelheim GmbH is acknowledged for generously providing TNF-a .

PY - 2000

Y1 - 2000

N2 - Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-α) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant sixfold increase in melphalan tumour tissue concentration after ILP when TNF-α was added to the perfusate, which provides a straightforward explanation for the observed synergism between melphalan and TNF-α in ILP. (C) 2000 Cancer Research Campaign.

AB - Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-α) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant sixfold increase in melphalan tumour tissue concentration after ILP when TNF-α was added to the perfusate, which provides a straightforward explanation for the observed synergism between melphalan and TNF-α in ILP. (C) 2000 Cancer Research Campaign.

KW - Isolated limb perfusion

KW - Melphalan

KW - Rats

KW - TNF

KW - Tissue concentration

UR - https://www.scopus.com/pages/publications/0034012752

U2 - 10.1054/bjoc.1999.1032

DO - 10.1054/bjoc.1999.1032

M3 - Article

C2 - 10737379

AN - SCOPUS:0034012752

SN - 0007-0920

VL - 82

SP - 1000

EP - 1003

JO - British journal of cancer

JF - British journal of cancer

IS - 5

ER -

Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion

Abstract

Keywords

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