Abstract
The capacity of the 3D-organoid cultures to resemble a near-physiological tissue organization and to mimic - to a certain degree - organ functionality, make organoids an excellent model for applications spanning from basic developmental/stem cell research to personalized medicine. Here, we review key findings achieved through organoid technology, and we discuss applications such as disease - and tumour modelling, correction of genetic mutations and understanding gene - and cell functions. Finally, we discuss future developments in the field.
| Original language | English |
|---|---|
| Pages (from-to) | R99-R107 |
| Journal | Human molecular genetics |
| Volume | 27 |
| Issue number | R2 |
| DOIs | |
| Publication status | Published - 1 Aug 2018 |
| Externally published | Yes |
Keywords
- Animals
- Cell Culture Techniques/methods
- Cell Differentiation/physiology
- Genetic Techniques
- Genetics
- Humans
- Models, Biological
- Organoids/metabolism
- Precision Medicine/methods
- Stem Cells
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