Validity of simplified 3′-Deoxy-3′-[18F] fluorothymidine uptake measures for monitoring response to chemotherapy in locally advanced breast cancer

Mark Lubberink, Wieteke Direcks, Jasper Emmering, Harm Van Tinteren, Otto S. Hoekstra, Jacobus J. Van Der Hoeven, Carla F.M. Molthoff, Adriaan A. Lammertsma

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21 Citations (Scopus)

Abstract

Purpose: Positron emission tomography using 3′-deoxy-3′-[ 18F]fluorothymidine ([18F]FLT) has been suggested as a means for monitoring response to chemotherapy. The aim of this study was to evaluate the validity of simplified uptake measures for assessing response to chemotherapy using [18F]FLT in locally advanced breast cancer (LABC). Procedures: Fifteen LABC patients underwent dynamic [18F]FLT scans both prior to and after the first cycle of chemotherapy with fluorouracil, epirubicin or doxorubicin, and cyclophosphamide. The net uptake rate constant of [18F]FLT, Ki, determined by non-linear regression (NLR) of an irreversible two-tissue compartment model was used as the gold standard. In addition to Patlak graphical analysis, standardised uptake values (SUV) and tumour-to-whole blood ratio (TBR) were used for analysing [18F]FLT data. Correlations and relationships between simplified uptake measures and NLR before and after chemotherapy were assessed using regression analysis. Results: No significant differences in both pre- and post-chemotherapy relationships between any of the simplified uptake measures and NLR were found. However, changes in SUV between baseline and post-therapy scans showed a significant negative bias and slope less than one, while TBR did not. Conclusions: In LABC, TBR instead of SUV may be preferred for monitoring response to chemotherapy with [18F]FLT.

Original languageEnglish
Pages (from-to)777-782
Number of pages6
JournalMolecular Imaging and Biology
Volume14
Issue number6
DOIs
Publication statusPublished - Dec 2012
Externally publishedYes

Keywords

  • FLT
  • Modelling
  • PET
  • Response monitoring
  • SUV

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