Vascular endothelial growth factor-A165 induces progression of melanoma brain metastases without induction of sprouting angiogenesis

Benno Küsters; William P.J. Leenders; Pieter Wesseling; Debby Smits; Kiek Verrijp; Dirk J. Ruiter; Johannes P.W. Peters; Albert J. Van der Kogel; Robert M.W. De Waal

Vascular endothelial growth factor-A₁₆₅ induces progression of melanoma brain metastases without induction of sprouting angiogenesis

Benno Küsters
, William P.J. Leenders
, Pieter Wesseling
, Debby Smits
, Kiek Verrijp
, Dirk J. Ruiter
, Johannes P.W. Peters
, Albert J. Van der Kogel
, Robert M.W. De Waal

Research output: Contribution to journal › Article › peer-review

150 Citations (Scopus)

Abstract

We investigated the mechanisms of vascularization in a brain metastases model of malignant melanoma. Parenchymal metastases expressing little vascular endothelial growth factor-A (VEGF-A) co-opted the preexistent brain vasculature, leading to an infiltrative phenotype. Metastases of the human melanoma cell line Mell57, engineered to express recombinant VEGF-A₁₆₅, showed accelerated growth in a combined expansive and infiltrative pattern with marked central necrosis. This difference in growth profile was accompanied by dilation of co-opted intra- and peritumoral vessels with concomitant induction of vascular permeability. Our data show that modulation of preexistent vasculature can contribute to malignant progression without induction of sprouting angiogenesis.

Original language	English
Pages (from-to)	341-345
Number of pages	5
Journal	Cancer Research
Volume	62
Issue number	2
Publication status	Published - 15 Jan 2002
Externally published	Yes

Cite this

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title = "Vascular endothelial growth factor-A165 induces progression of melanoma brain metastases without induction of sprouting angiogenesis",

abstract = "We investigated the mechanisms of vascularization in a brain metastases model of malignant melanoma. Parenchymal metastases expressing little vascular endothelial growth factor-A (VEGF-A) co-opted the preexistent brain vasculature, leading to an infiltrative phenotype. Metastases of the human melanoma cell line Mell57, engineered to express recombinant VEGF-A165, showed accelerated growth in a combined expansive and infiltrative pattern with marked central necrosis. This difference in growth profile was accompanied by dilation of co-opted intra- and peritumoral vessels with concomitant induction of vascular permeability. Our data show that modulation of preexistent vasculature can contribute to malignant progression without induction of sprouting angiogenesis.",

author = "Benno K{\"u}sters and Leenders, \{William P.J.\} and Pieter Wesseling and Debby Smits and Kiek Verrijp and Ruiter, \{Dirk J.\} and Peters, \{Johannes P.W.\} and \{Van der Kogel\}, \{Albert J.\} and \{De Waal\}, \{Robert M.W.\}",

year = "2002",

month = jan,

day = "15",

language = "English",

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pages = "341--345",

journal = "Cancer Research",

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publisher = "American Association for Cancer Research Inc.",

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TY - JOUR

T1 - Vascular endothelial growth factor-A165 induces progression of melanoma brain metastases without induction of sprouting angiogenesis

AU - Küsters, Benno

AU - Leenders, William P.J.

AU - Wesseling, Pieter

AU - Smits, Debby

AU - Verrijp, Kiek

AU - Ruiter, Dirk J.

AU - Peters, Johannes P.W.

AU - Van der Kogel, Albert J.

AU - De Waal, Robert M.W.

PY - 2002/1/15

Y1 - 2002/1/15

N2 - We investigated the mechanisms of vascularization in a brain metastases model of malignant melanoma. Parenchymal metastases expressing little vascular endothelial growth factor-A (VEGF-A) co-opted the preexistent brain vasculature, leading to an infiltrative phenotype. Metastases of the human melanoma cell line Mell57, engineered to express recombinant VEGF-A165, showed accelerated growth in a combined expansive and infiltrative pattern with marked central necrosis. This difference in growth profile was accompanied by dilation of co-opted intra- and peritumoral vessels with concomitant induction of vascular permeability. Our data show that modulation of preexistent vasculature can contribute to malignant progression without induction of sprouting angiogenesis.

AB - We investigated the mechanisms of vascularization in a brain metastases model of malignant melanoma. Parenchymal metastases expressing little vascular endothelial growth factor-A (VEGF-A) co-opted the preexistent brain vasculature, leading to an infiltrative phenotype. Metastases of the human melanoma cell line Mell57, engineered to express recombinant VEGF-A165, showed accelerated growth in a combined expansive and infiltrative pattern with marked central necrosis. This difference in growth profile was accompanied by dilation of co-opted intra- and peritumoral vessels with concomitant induction of vascular permeability. Our data show that modulation of preexistent vasculature can contribute to malignant progression without induction of sprouting angiogenesis.

UR - https://www.scopus.com/pages/publications/0037081299

M3 - Article

C2 - 11809675

AN - SCOPUS:0037081299

SN - 0008-5472

VL - 62

SP - 341

EP - 345

JO - Cancer Research

JF - Cancer Research

IS - 2

ER -

Vascular endothelial growth factor-A165 induces progression of melanoma brain metastases without induction of sprouting angiogenesis

Abstract

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Vascular endothelial growth factor-A₁₆₅ induces progression of melanoma brain metastases without induction of sprouting angiogenesis