Wnt/β-catenin signaling and disease

Hans Clevers; Roel Nusse

doi:10.1016/j.cell.2012.05.012

Wnt/β-catenin signaling and disease

Hans Clevers
, Roel Nusse

Research output: Contribution to journal › Review article › peer-review

4991 Citations (Scopus)

Abstract

The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.

Original language	English
Pages (from-to)	1192-1205
Number of pages	14
Journal	Cell
Volume	149
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2012.05.012
Publication status	Published - 8 Jun 2012
Externally published	Yes

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10.1016/j.cell.2012.05.012

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title = "Wnt/β-catenin signaling and disease",

abstract = "The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.",

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AU - Nusse, Roel

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AB - The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.

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U2 - 10.1016/j.cell.2012.05.012

DO - 10.1016/j.cell.2012.05.012

M3 - Review article

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AN - SCOPUS:84861986053

SN - 0092-8674

VL - 149

SP - 1192

EP - 1205

JO - Cell

JF - Cell

IS - 6

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Wnt/β-catenin signaling and disease

Abstract

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