Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

Roel Nusse, Hans Clevers

Research output: Contribution to journalReview articlepeer-review

2886 Citations (Scopus)


The WNT signal transduction cascade is a main regulator of development throughout the animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult mammals. Unsurprisingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to cancer. Here, we describe the core Wnt/β-catenin signaling pathway, how it controls stem cells, and contributes to disease. Finally, we discuss strategies for Wnt-based therapies.

Original languageEnglish
Pages (from-to)985-999
Number of pages15
Issue number6
Publication statusPublished - 1 Jun 2017


  • cancer
  • development
  • stem cells
  • therapy
  • Wnt


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