Wnt/β-Catenin Signaling in Development and Disease

Hans Clevers

doi:10.1016/j.cell.2006.10.018

Wnt/β-Catenin Signaling in Development and Disease

Hans Clevers

Research output: Contribution to journal › Review article › peer-review

5029 Citations (Scopus)

Abstract

A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades. Wnt genes encode small secreted proteins that are found in all animal genomes. Wnt signaling is involved in virtually every aspect of embryonic development and also controls homeostatic self-renewal in a number of adult tissues. Germline mutations in the Wnt pathway cause several hereditary diseases, and somatic mutations are associated with cancer of the intestine and a variety of other tissues.

Original language	English
Pages (from-to)	469-480
Number of pages	12
Journal	Cell
Volume	127
Issue number	3
DOIs	https://doi.org/10.1016/j.cell.2006.10.018
Publication status	Published - 3 Nov 2006
Externally published	Yes

Access to Document

10.1016/j.cell.2006.10.018

Cite this

@article{e463e32fde544ad39c1118a3829205d3,

title = "Wnt/β-Catenin Signaling in Development and Disease",

abstract = "A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades. Wnt genes encode small secreted proteins that are found in all animal genomes. Wnt signaling is involved in virtually every aspect of embryonic development and also controls homeostatic self-renewal in a number of adult tissues. Germline mutations in the Wnt pathway cause several hereditary diseases, and somatic mutations are associated with cancer of the intestine and a variety of other tissues.",

author = "Hans Clevers",

year = "2006",

month = nov,

day = "3",

doi = "10.1016/j.cell.2006.10.018",

language = "English",

volume = "127",

pages = "469--480",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "3",

}

TY - JOUR

T1 - Wnt/β-Catenin Signaling in Development and Disease

AU - Clevers, Hans

PY - 2006/11/3

Y1 - 2006/11/3

N2 - A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades. Wnt genes encode small secreted proteins that are found in all animal genomes. Wnt signaling is involved in virtually every aspect of embryonic development and also controls homeostatic self-renewal in a number of adult tissues. Germline mutations in the Wnt pathway cause several hereditary diseases, and somatic mutations are associated with cancer of the intestine and a variety of other tissues.

AB - A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades. Wnt genes encode small secreted proteins that are found in all animal genomes. Wnt signaling is involved in virtually every aspect of embryonic development and also controls homeostatic self-renewal in a number of adult tissues. Germline mutations in the Wnt pathway cause several hereditary diseases, and somatic mutations are associated with cancer of the intestine and a variety of other tissues.

UR - https://www.scopus.com/pages/publications/33746808398

U2 - 10.1016/j.cell.2006.10.018

DO - 10.1016/j.cell.2006.10.018

M3 - Review article

C2 - 17081971

AN - SCOPUS:33746808398

SN - 0092-8674

VL - 127

SP - 469

EP - 480

JO - Cell

JF - Cell

IS - 3

ER -

Wnt/β-Catenin Signaling in Development and Disease

Abstract

Access to Document

Fingerprint

Cite this