Wnt signaling: Ig-Norrin the dogma

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28 Citations (Scopus)


Secreted Wnt proteins trigger the intracellular Wnt signaling cascade upon engagement of dedicated Frizzled-Lrp receptor complexes. Unexpectedly, a non-Wnt ligand for this receptor complex has now been discovered. This novel ligand, Norrin, is mutated in the hereditary ocular Norrie syndrome.

Original languageEnglish
Pages (from-to)R436-R437
JournalCurrent Biology
Issue number11
Publication statusPublished - 8 Jun 2004
Externally publishedYes


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