Wnt signaling: Ig-Norrin the dogma

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)

Abstract

Secreted Wnt proteins trigger the intracellular Wnt signaling cascade upon engagement of dedicated Frizzled-Lrp receptor complexes. Unexpectedly, a non-Wnt ligand for this receptor complex has now been discovered. This novel ligand, Norrin, is mutated in the hereditary ocular Norrie syndrome.

Original languageEnglish
Pages (from-to)R436-R437
JournalCurrent Biology
Volume14
Issue number11
DOIs
Publication statusPublished - 8 Jun 2004
Externally publishedYes

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