Abstract
Secreted Wnt proteins trigger the intracellular Wnt signaling cascade upon engagement of dedicated Frizzled-Lrp receptor complexes. Unexpectedly, a non-Wnt ligand for this receptor complex has now been discovered. This novel ligand, Norrin, is mutated in the hereditary ocular Norrie syndrome.
| Original language | English |
|---|---|
| Pages (from-to) | R436-R437 |
| Journal | Current Biology |
| Volume | 14 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 8 Jun 2004 |
| Externally published | Yes |