WNT signalling and haematopoiesis: A WNT-WNT situation

Frank J.T. Staal; Hans C. Clevers

doi:10.1038/nri1529

WNT signalling and haematopoiesis: A WNT-WNT situation

Frank J.T. Staal
, Hans C. Clevers

Research output: Contribution to journal › Review article › peer-review

300 Citations (Scopus)

Abstract

The evolutionarily conserved WNT-signalling pathway has pivotal roles during the development of many organ systems, and dysregulated WNT signalling is a key factor in the initiation of various tumours. Recent studies have implicated a role for WNT signal transduction at several stages of lymphocyte development and in the self-renewal of haematopoietic stem cells. Here, we outline new insights into the WNT-signalling pathway, review its role in the self-renewal of haematopoietic stem cells and in the development of T and B cells, and discuss controversies and future developments with regard to WNT signalling in the thymus.

Original language	English
Pages (from-to)	21-30
Number of pages	10
Journal	Nature Reviews Immunology
Volume	5
Issue number	1
DOIs	https://doi.org/10.1038/nri1529
Publication status	Published - Jan 2005
Externally published	Yes

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title = "WNT signalling and haematopoiesis: A WNT-WNT situation",

abstract = "The evolutionarily conserved WNT-signalling pathway has pivotal roles during the development of many organ systems, and dysregulated WNT signalling is a key factor in the initiation of various tumours. Recent studies have implicated a role for WNT signal transduction at several stages of lymphocyte development and in the self-renewal of haematopoietic stem cells. Here, we outline new insights into the WNT-signalling pathway, review its role in the self-renewal of haematopoietic stem cells and in the development of T and B cells, and discuss controversies and future developments with regard to WNT signalling in the thymus.",

author = "Staal, \{Frank J.T.\} and Clevers, \{Hans C.\}",

note = "Funding Information: We thank C. E. van der Linden for careful reading of the manuscript. F.J.T.S. is supported by grants from NWO (The Netherlands), the Fifth and Sixth Framework Programmes (European Union) and the Bekales Foundation (Belgium).",

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AU - Clevers, Hans C.

N1 - Funding Information: We thank C. E. van der Linden for careful reading of the manuscript. F.J.T.S. is supported by grants from NWO (The Netherlands), the Fifth and Sixth Framework Programmes (European Union) and the Bekales Foundation (Belgium).

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N2 - The evolutionarily conserved WNT-signalling pathway has pivotal roles during the development of many organ systems, and dysregulated WNT signalling is a key factor in the initiation of various tumours. Recent studies have implicated a role for WNT signal transduction at several stages of lymphocyte development and in the self-renewal of haematopoietic stem cells. Here, we outline new insights into the WNT-signalling pathway, review its role in the self-renewal of haematopoietic stem cells and in the development of T and B cells, and discuss controversies and future developments with regard to WNT signalling in the thymus.

AB - The evolutionarily conserved WNT-signalling pathway has pivotal roles during the development of many organ systems, and dysregulated WNT signalling is a key factor in the initiation of various tumours. Recent studies have implicated a role for WNT signal transduction at several stages of lymphocyte development and in the self-renewal of haematopoietic stem cells. Here, we outline new insights into the WNT-signalling pathway, review its role in the self-renewal of haematopoietic stem cells and in the development of T and B cells, and discuss controversies and future developments with regard to WNT signalling in the thymus.

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M3 - Review article

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VL - 5

SP - 21

EP - 30

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

IS - 1

ER -

WNT signalling and haematopoiesis: A WNT-WNT situation

Abstract

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