Wnt, stem cells and cancer in the intestine

Daniel Pinto, Hans Clevers

Research output: Contribution to journalReview articlepeer-review

145 Citations (Scopus)

Abstract

The intestinal epithelium is a self-renewing tissue which represents a unique model for studying interconnected cellular processes such as proliferation, differentiation, cell migration and carcinogenesis. Although the stem cells of the intestine have not yet been physically characterized or isolated, data over the past decade have strongly implicated the Wnt/β-catenin signalling pathway in their maintenance and progression to cancer. This review will (i) describe the distinctive features of the intestinal epithelium in relation to stem-cell function, (ii) illustrate the major genetic alterations that can lead to cancer, and (iii) show how Wnt/β-catenin signalling controls homoeostasis in this tissue.

Original languageEnglish
Pages (from-to)185-196
Number of pages12
JournalBiology of the Cell
Volume97
Issue number3
DOIs
Publication statusPublished - Mar 2005
Externally publishedYes

Keywords

  • Colorectal cancer (CRC)
  • Intestinal epithelium
  • Wnt/β-catenin signalling

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