TY - JOUR
T1 - 18 F-FDG-PET/CT imaging in diagnostic workup of pediatric precursor B-cell lymphoblastic lymphoma
AU - Kroeze, Emma
AU - Padilla, Laura Arias
AU - Burkhardt, Birgit
AU - Attarbaschi, Andishe
AU - von Mersi, Hannah
AU - Kebudi, Rejin
AU - Nievelstein, Rutger A J
AU - Tolboom, Nelleke
AU - Hagleitner, Melanie M
AU - Kuiper, Roland P
AU - Beishuizen, Auke
AU - Loeffen, Jan L C
N1 - © 2023 Wiley Periodicals LLC.
PY - 2023/1
Y1 - 2023/1
N2 - 18 F-fluorodeoxyglucose-positron emission tomography/computed tomography (PET/CT) imaging is currently not used in standard diagnostics for B-cell precursor lymphoblastic lymphoma (BCP-LBL), and it is unknown whether PET/CT imaging would lead to agreement between detection of lesions with the gold standard imaging methods. Therefore, we performed a retrospective cohort study in which we included 32 pediatric BCP-LBL patients and determined localizations by reviewing local imaging reports. There was a disagreement between protocol-based imaging and PET/CT in 59% of the patients, and the discrepancies mostly comprise of additional lesions detected with PET/CT, typically in lymph node and bone or the absence of bone marrow involvement with PET/CT. If PET/CT was leading in determining definite stage of disease, this would lead to a different stage and therapy branch in 31% and 28% of the patients, respectively.
AB - 18 F-fluorodeoxyglucose-positron emission tomography/computed tomography (PET/CT) imaging is currently not used in standard diagnostics for B-cell precursor lymphoblastic lymphoma (BCP-LBL), and it is unknown whether PET/CT imaging would lead to agreement between detection of lesions with the gold standard imaging methods. Therefore, we performed a retrospective cohort study in which we included 32 pediatric BCP-LBL patients and determined localizations by reviewing local imaging reports. There was a disagreement between protocol-based imaging and PET/CT in 59% of the patients, and the discrepancies mostly comprise of additional lesions detected with PET/CT, typically in lymph node and bone or the absence of bone marrow involvement with PET/CT. If PET/CT was leading in determining definite stage of disease, this would lead to a different stage and therapy branch in 31% and 28% of the patients, respectively.
KW - Humans
KW - Child
KW - Fluorodeoxyglucose F18
KW - Positron Emission Tomography Computed Tomography
KW - Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/diagnostic imaging
KW - Retrospective Studies
KW - Diagnostic Imaging
UR - https://www.mendeley.com/catalogue/ff7acf59-1b6f-3fbb-b8ab-e7d55f3507c0/
U2 - 10.1002/pbc.30642
DO - 10.1002/pbc.30642
M3 - Article
C2 - 37638834
SN - 1545-5009
VL - 70
SP - e30642
JO - Pediatric blood & cancer
JF - Pediatric blood & cancer
IS - 11
ER -