TY - JOUR
T1 - A 14-year-old girl with premature ovarian insufficiency but with a positive pregnancy test
AU - Touwslager, Robbert N H
AU - Zwaan, C Michel
AU - Bakker, Boudewijn
AU - Lentjes, Eef G W M
AU - Looijenga, Leendert H J
AU - van Santen, Hanneke M
N1 - © 2024 the author(s), published by De Gruyter, Berlin/Boston.
PY - 2024/5/27
Y1 - 2024/5/27
N2 - OBJECTIVES: Childhood cancer survivors are at risk for premature ovarian insufficiency, especially after treatment with alkylating agents. The objective of this report is to highlight a case in which this phenomenon caused a false-positive pregnancy test.CASE PRESENTATION: A workup was performed in a 14-year-old girl with a positive pregnancy test. She was diagnosed with stage IV neuroblastoma of the left adrenal gland at the age of 4 years. She received extensive treatment, including alkylating agents, and had been diagnosed with premature ovarian insufficiency. An LH/hCG suppression test was performed using high dose 17 bèta-estradiol: hCG levels normalized.CONCLUSIONS: The pregnancy test was false-positive due to production of low amounts of hCG by the pituitary gland as a result of high LH concentrations following premature ovarian insufficiency. It may be helpful to perform the LH/hCG suppression test to prove pituitary origin of the hCG overproduction.
AB - OBJECTIVES: Childhood cancer survivors are at risk for premature ovarian insufficiency, especially after treatment with alkylating agents. The objective of this report is to highlight a case in which this phenomenon caused a false-positive pregnancy test.CASE PRESENTATION: A workup was performed in a 14-year-old girl with a positive pregnancy test. She was diagnosed with stage IV neuroblastoma of the left adrenal gland at the age of 4 years. She received extensive treatment, including alkylating agents, and had been diagnosed with premature ovarian insufficiency. An LH/hCG suppression test was performed using high dose 17 bèta-estradiol: hCG levels normalized.CONCLUSIONS: The pregnancy test was false-positive due to production of low amounts of hCG by the pituitary gland as a result of high LH concentrations following premature ovarian insufficiency. It may be helpful to perform the LH/hCG suppression test to prove pituitary origin of the hCG overproduction.
KW - childhood cancer survivors
KW - human chorionic gonadotropin
KW - pituitary gland
KW - premature ovarian insufficiency
KW - teenage pregnancy
KW - Adolescent
KW - Adrenal Gland Neoplasms/complications
KW - False Positive Reactions
KW - Female
KW - Humans
KW - Luteinizing Hormone/blood
KW - Neuroblastoma/complications
KW - Pregnancy
KW - Pregnancy Tests
KW - Primary Ovarian Insufficiency/diagnosis
KW - Prognosis
UR - https://www.mendeley.com/catalogue/c5b6bbe6-2f9c-3491-9ebe-2a12989b56d2/
U2 - 10.1515/jpem-2024-0019
DO - 10.1515/jpem-2024-0019
M3 - Article
C2 - 38618883
SN - 0334-018X
VL - 37
SP - 482
EP - 485
JO - Journal of Pediatric Endocrinology and Metabolism
JF - Journal of Pediatric Endocrinology and Metabolism
IS - 5
ER -