A 14-year-old girl with premature ovarian insufficiency but with a positive pregnancy test

Robbert N H Touwslager, C Michel Zwaan, Boudewijn Bakker, Eef G W M Lentjes, Leendert H J Looijenga, Hanneke M van Santen

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review


OBJECTIVES: Childhood cancer survivors are at risk for premature ovarian insufficiency, especially after treatment with alkylating agents. The objective of this report is to highlight a case in which this phenomenon caused a false-positive pregnancy test.

CASE PRESENTATION: A workup was performed in a 14-year-old girl with a positive pregnancy test. She was diagnosed with stage IV neuroblastoma of the left adrenal gland at the age of 4 years. She received extensive treatment, including alkylating agents, and had been diagnosed with premature ovarian insufficiency. An LH/hCG suppression test was performed using high dose 17 bèta-estradiol: hCG levels normalized.

CONCLUSIONS: The pregnancy test was false-positive due to production of low amounts of hCG by the pituitary gland as a result of high LH concentrations following premature ovarian insufficiency. It may be helpful to perform the LH/hCG suppression test to prove pituitary origin of the hCG overproduction.

Originele taal-2Engels
Pagina's (van-tot)482-485
Aantal pagina's4
TijdschriftJournal of Pediatric Endocrinology and Metabolism
Nummer van het tijdschrift5
Vroegere onlinedatum15 apr. 2024
StatusE-publicatie vóór gedrukte publicatie - 15 apr. 2024


  • childhood cancer survivors
  • human chorionic gonadotropin
  • pituitary gland
  • premature ovarian insufficiency
  • teenage pregnancy


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