A central role for P48/45 in malaria parasite male gamete fertility

Melissa R. Van Dijk, Chris J. Janse, Joanne Thompson, Andrew P. Waters, Joanna A.M. Braks, Huub J. Dodemont, Henk G. Stunnenberg, Geert Jan Van Gemert, Robert W. Sauerwein, Wijnand Eling

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

309 Citaten (Scopus)


Fertilization and zygote development are obligate features of the malaria parasite life cycle and occur during parasite transmission to mosquitoes. The surface protein PFS48/45 is expressed by male and female gametes of Plasmodium falciparum and PFS48/45 antibodies prevent zygote development and transmission. Here, gene disruption was used to show that Pfs48/45 and the ortholog Pbs48/45 from a rodent malaria parasite P. berghei play a conserved and important role in fertilization. p48/45- parasites had a reduced capacity to produce oocysts in mosquitoes due to greatly reduced zygote formation. Unexpectedly, only male gamete fertility of p48/45- parasites was affected, failing to penetrate otherwise fertile female gametes. P48/45 is shown to be a surface protein of malaria parasites with a demonstrable role in fertilization.

Originele taal-2Engels
Pagina's (van-tot)153-164
Aantal pagina's12
Nummer van het tijdschrift1
StatusGepubliceerd - 12 jan. 2001
Extern gepubliceerdJa


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