A comparison of the in vitro cytotoxicity of daunorubicin and liposomal daunorubicin in pediatric acute leukemia

Bianca F. Goemans; Christian M. Zwaan; Dirk Reinhardt; Brenda E.S. Gibson; K. Hählen; Gert Jan L. Kaspers

A comparison of the in vitro cytotoxicity of daunorubicin and liposomal daunorubicin in pediatric acute leukemia

Bianca F. Goemans, Christian M. Zwaan, Dirk Reinhardt, Brenda E.S. Gibson, K. Hählen, Gert Jan L. Kaspers

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

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Anthracyclines are effective in the treatment of leukemia, but their use is limited because of cardiotoxicity. Liposomal daunorubicin (L-DNR) is potentially less cardiotoxic than daunorubicin (DNR). We compared in vitro cytotoxicity in pediatric acute leukemia samples and found no significant differences between cytotoxicity of DNR and L-DNR.

Originele taal-2	Engels
Pagina's (van-tot)	1573-1574
Aantal pagina's	2
Tijdschrift	Haematologica
Volume	91
Nummer van het tijdschrift	11
Status	Gepubliceerd - nov. 2006
Extern gepubliceerd	Ja

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title = "A comparison of the in vitro cytotoxicity of daunorubicin and liposomal daunorubicin in pediatric acute leukemia",

abstract = "Anthracyclines are effective in the treatment of leukemia, but their use is limited because of cardiotoxicity. Liposomal daunorubicin (L-DNR) is potentially less cardiotoxic than daunorubicin (DNR). We compared in vitro cytotoxicity in pediatric acute leukemia samples and found no significant differences between cytotoxicity of DNR and L-DNR.",

keywords = "Cardiotoxicity, Drug sensitivity, Liposomal daunombicin, Pediatric acute leukemia",

author = "Goemans, {Bianca F.} and Zwaan, {Christian M.} and Dirk Reinhardt and Gibson, {Brenda E.S.} and K. H{\"a}hlen and Kaspers, {Gert Jan L.}",

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T1 - A comparison of the in vitro cytotoxicity of daunorubicin and liposomal daunorubicin in pediatric acute leukemia

AU - Goemans, Bianca F.

AU - Zwaan, Christian M.

AU - Reinhardt, Dirk

AU - Gibson, Brenda E.S.

AU - Hählen, K.

AU - Kaspers, Gert Jan L.

PY - 2006/11

Y1 - 2006/11

N2 - Anthracyclines are effective in the treatment of leukemia, but their use is limited because of cardiotoxicity. Liposomal daunorubicin (L-DNR) is potentially less cardiotoxic than daunorubicin (DNR). We compared in vitro cytotoxicity in pediatric acute leukemia samples and found no significant differences between cytotoxicity of DNR and L-DNR.

AB - Anthracyclines are effective in the treatment of leukemia, but their use is limited because of cardiotoxicity. Liposomal daunorubicin (L-DNR) is potentially less cardiotoxic than daunorubicin (DNR). We compared in vitro cytotoxicity in pediatric acute leukemia samples and found no significant differences between cytotoxicity of DNR and L-DNR.

KW - Cardiotoxicity

KW - Drug sensitivity

KW - Liposomal daunombicin

KW - Pediatric acute leukemia

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M3 - Article

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AN - SCOPUS:33750933843

SN - 0390-6078

VL - 91

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JO - Haematologica

JF - Haematologica

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ER -

A comparison of the in vitro cytotoxicity of daunorubicin and liposomal daunorubicin in pediatric acute leukemia

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