TY - JOUR
T1 - A detailed insight in the high risks of hospitalizations in long-term childhood cancer survivors-A Dutch LATER linkage study
AU - Dutch LATER Study group
AU - Streefkerk, Nina
AU - Tissing, Wim J E
AU - Korevaar, Joke C
AU - van Dulmen-den Broeder, Eline
AU - Bresters, Dorine
AU - van der Heiden-van der Loo, Margriet
AU - van de Heuvel-Eibrink, Marry M
AU - Van Leeuwen, Flora E
AU - Loonen, Jacqueline
AU - van der Pal, Helena H J
AU - Ronckers, Cecile M
AU - Versluys, A Brigitta
AU - de Vries, Andrica C H
AU - Feijen, Elizabeth A M
AU - Kremer, Leontine C M
N1 - Publisher Copyright:
© 2020 Streefkerk et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2020
Y1 - 2020
N2 - BACKGROUND: Insight in hospitalizations in long-term childhood cancer survivors (CCS) is useful to understand the impact of long-term morbidity. We aimed to investigate hospitalization rates and underlying types of diagnoses in CCS compared to matched controls, and to investigate the determinants.METHODS: We linked 5,650 five-year CCS from the Dutch nationwide Dutch LATER cohort and 109,605 age- and sex-matched controls to the Dutch Hospital Discharge register, which contained detailed information on inpatient hospitalizations from 1995-2016. Relative hospitalization rates (RHRs) were calculated using a Poisson regression model. Adjusting for multiple hospitalizations per person via a Poisson model for generalized estimated equations, we investigated determinants for hospitalizations for all types of underlying diagnoses among CCS.RESULTS: CCS were twice as likely to be hospitalized as reference persons (hospitalization rate 178 and 78 per 1,000 person-years respectively; RHR 2.0, 95% confidence interval (CI) 1.9-2.2). Although CCS had more hospitalizations for 17 types of underlying diagnoses, they were especially more likely to be hospitalized for endocrine conditions (RHR: 6.0, 95% CI 4.6-7.7), subsequent neoplasms (RHR: 5.6, 95% CI 4.6-6.7) and symptoms without underlying diagnoses (RHR: 5.2, 95% CI 4.6-5.8). For those types of underlying diagnoses, female sex and radiotherapy were determinants.CONCLUSION: This study provides new insights in the high risk of hospitalizations for many types of underlying diagnoses in CCS and treatment related determinants. CCS are especially at high risk for hospitalizations for endocrine conditions, subsequent neoplasms and symptoms without an underlying diagnosis. This new knowledge is important for survivorship care and to identify possible preventable hospitalizations among CCS.
AB - BACKGROUND: Insight in hospitalizations in long-term childhood cancer survivors (CCS) is useful to understand the impact of long-term morbidity. We aimed to investigate hospitalization rates and underlying types of diagnoses in CCS compared to matched controls, and to investigate the determinants.METHODS: We linked 5,650 five-year CCS from the Dutch nationwide Dutch LATER cohort and 109,605 age- and sex-matched controls to the Dutch Hospital Discharge register, which contained detailed information on inpatient hospitalizations from 1995-2016. Relative hospitalization rates (RHRs) were calculated using a Poisson regression model. Adjusting for multiple hospitalizations per person via a Poisson model for generalized estimated equations, we investigated determinants for hospitalizations for all types of underlying diagnoses among CCS.RESULTS: CCS were twice as likely to be hospitalized as reference persons (hospitalization rate 178 and 78 per 1,000 person-years respectively; RHR 2.0, 95% confidence interval (CI) 1.9-2.2). Although CCS had more hospitalizations for 17 types of underlying diagnoses, they were especially more likely to be hospitalized for endocrine conditions (RHR: 6.0, 95% CI 4.6-7.7), subsequent neoplasms (RHR: 5.6, 95% CI 4.6-6.7) and symptoms without underlying diagnoses (RHR: 5.2, 95% CI 4.6-5.8). For those types of underlying diagnoses, female sex and radiotherapy were determinants.CONCLUSION: This study provides new insights in the high risk of hospitalizations for many types of underlying diagnoses in CCS and treatment related determinants. CCS are especially at high risk for hospitalizations for endocrine conditions, subsequent neoplasms and symptoms without an underlying diagnosis. This new knowledge is important for survivorship care and to identify possible preventable hospitalizations among CCS.
KW - Adolescent
KW - Cancer Survivors/statistics & numerical data
KW - Child
KW - Child, Preschool
KW - Female
KW - Hospitalization
KW - Humans
KW - Infant
KW - Infant, Newborn
KW - Male
KW - Multivariate Analysis
KW - Netherlands/epidemiology
KW - Risk Factors
KW - Young Adult
UR - http://www.scopus.com/inward/record.url?scp=85084964875&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0232708
DO - 10.1371/journal.pone.0232708
M3 - Article
C2 - 32427994
SN - 1932-6203
VL - 15
SP - e0232708
JO - PloS one
JF - PloS one
IS - 5
M1 - e0232708
ER -