TY - JOUR
T1 - A malignant mixed gonadal stromal tumor of the testis with heterologous components and i(12p) in one of its metastases
AU - Oosterhuis, J. Wolter
AU - Castedo, Sergio M.M.J.
AU - de Jong, Bauke
AU - Seruca, Raquel
AU - Dam, Anke
AU - Vos, Anne Marie
AU - de Koning, Jos
AU - Schraffordt Koops, Heimen
AU - Sleijfer, Dirk Th
N1 - Funding Information:
This work was supported by grants GUKC 84-6 and FGUKC 88-10 from the Netherlands Cancer Foundation (K. W. F.), and by grants from the Pediatric Oncology Foundation Groningen (S. K. O. G.), the Jan Kornelis de Cock Stichting and the Hubrecht Laboratorium, Utrecht, The Netherlands.
PY - 1989/8
Y1 - 1989/8
N2 - A malignant mixed gonadal stromal tumor with mesenchymal heterologous elements of the testis is presented. This entity has been described in the ovary, but not hitherto in the testis. Karyotyping and ploidy measurement was done of the primary tumor and of an inguinal and lung metastases. The DNA ploidy and modal chromosome numbers were in agreement with each other in all samples. The most significant cytogenetic finding was the presence of the metacentric germ cell tumor marker i(12p) in an inguinal metastasis. This marker has been demonstrated in testicular and ovarian germ cell tumors and in a mixed Müllerian tumor, which raises the question of a possible relationship between the pluripotency of these tumors and the presence of i(12p).
AB - A malignant mixed gonadal stromal tumor with mesenchymal heterologous elements of the testis is presented. This entity has been described in the ovary, but not hitherto in the testis. Karyotyping and ploidy measurement was done of the primary tumor and of an inguinal and lung metastases. The DNA ploidy and modal chromosome numbers were in agreement with each other in all samples. The most significant cytogenetic finding was the presence of the metacentric germ cell tumor marker i(12p) in an inguinal metastasis. This marker has been demonstrated in testicular and ovarian germ cell tumors and in a mixed Müllerian tumor, which raises the question of a possible relationship between the pluripotency of these tumors and the presence of i(12p).
UR - http://www.scopus.com/inward/record.url?scp=0024441365&partnerID=8YFLogxK
U2 - 10.1016/0165-4608(89)90114-3
DO - 10.1016/0165-4608(89)90114-3
M3 - Article
C2 - 2766245
AN - SCOPUS:0024441365
SN - 0165-4608
VL - 41
SP - 105
EP - 114
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 1
ER -