A model for the topology of active ribosomal RNA genes

Serguei Denissov, Frédéric Lessard, Christine Mayer, Victor Stefanovsky, Marc Van Driel, Ingrid Grummt, Tom Moss, Hendrik G. Stunnenberg

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

49 Citaten (Scopus)

Samenvatting

The Christmas tree view of active ribosomal RNA (rRNA) genes suggests a gene topology in which a large number of nascent rRNA transcripts are prevented from intertwining. The way in which this is achieved has remained unclear. By using a combination of chromatin immunoprecipitation and chromosome conformation capture techniques, we show that the promoter, upstream region and terminator R3 of active rRNA genes are held together spatially throughout the cell cycle, forming a stable core around which the transcribed region is organized. We suggest a new core-helix model for the topology of rRNA genes, that provides a structural basis for the productive synthesis or rRNA.

Originele taal-2Engels
Pagina's (van-tot)231-237
Aantal pagina's7
TijdschriftEMBO Reports
Volume12
Nummer van het tijdschrift3
DOI's
StatusGepubliceerd - mrt. 2011
Extern gepubliceerdJa

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