A multifaceted 'omics' approach for addressing the challenge of antimicrobial resistance

Asi Cohen, Louis Bont, Dan Engelhard, Edward Moore, David Fernández, Racheli Kreisberg-Greenblatt, Kfir Oved, Eran Eden, John P. Hays

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

23 Citaten (Scopus)

Samenvatting

The inappropriate use of antibiotics has severe global health and economic consequences, including the emergence of antibiotic-resistant bacteria. A major driver of antibiotic misuse is the inability to accurately distinguish between bacterial and viral infections based on currently available diagnostic solutions. A multifaceted 'omics' approach that integrates personalized patient data such as genetic predisposition to infections (genomics), natural microbiota composition and immune response to infection (proteomics and transcriptomics) together with comprehensive pathogen profiling has the potential to help physicians improve their antimicrobial prescribing practices. In this respect, the EU has funded a multidisciplinary project (TAILORED-Treatment) that will develop novel omics-based personalized treatment schemes that have the potential to reduce antibiotic consumption, and help limiting the spread of antibiotic resistance.

Originele taal-2Engels
Pagina's (van-tot)365-376
Aantal pagina's12
TijdschriftFuture Microbiology
Volume10
Nummer van het tijdschrift3
DOI's
StatusGepubliceerd - 1 mrt. 2015
Extern gepubliceerdJa

Vingerafdruk

Duik in de onderzoeksthema's van 'A multifaceted 'omics' approach for addressing the challenge of antimicrobial resistance'. Samen vormen ze een unieke vingerafdruk.

Citeer dit