A RAG driver on the road to pediatric ALL

Roland P Kuiper; Esmé Waanders

doi:10.1038/ng.2879

A RAG driver on the road to pediatric ALL

Roland P Kuiper
, Esmé Waanders

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel

4 Citaten (Scopus)

Samenvatting

Genomic aberrations affecting genes in B cell differentiation are hallmarks of B-precursor acute lymphoblastic leukemia (ALL). A new whole-genome sequencing study of ETV6-RUNX1-positive ALL has now identified RAG-mediated recombination, which specifically targets genes and regulatory elements active during B cell differentiation, as the underlying mechanism.

Originele taal-2	Engels
Pagina's (van-tot)	96-8
Aantal pagina's	3
Tijdschrift	Nature Genetics
Volume	46
Nummer van het tijdschrift	2
DOI's	https://doi.org/10.1038/ng.2879
Status	Gepubliceerd - feb. 2014
Extern gepubliceerd	Ja

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10.1038/ng.2879

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title = "A RAG driver on the road to pediatric ALL",

abstract = "Genomic aberrations affecting genes in B cell differentiation are hallmarks of B-precursor acute lymphoblastic leukemia (ALL). A new whole-genome sequencing study of ETV6-RUNX1-positive ALL has now identified RAG-mediated recombination, which specifically targets genes and regulatory elements active during B cell differentiation, as the underlying mechanism. ",

keywords = "Core Binding Factor Alpha 2 Subunit/genetics, Gene Expression Regulation, Neoplastic/genetics, Gene Rearrangement/genetics, Genetic Variation, Homeodomain Proteins/genetics, Humans, Oncogene Proteins, Fusion/genetics, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics, Recombination, Genetic/genetics",

author = "Kuiper, \{Roland P\} and Esm{\'e} Waanders",

year = "2014",

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doi = "10.1038/ng.2879",

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AU - Waanders, Esmé

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AB - Genomic aberrations affecting genes in B cell differentiation are hallmarks of B-precursor acute lymphoblastic leukemia (ALL). A new whole-genome sequencing study of ETV6-RUNX1-positive ALL has now identified RAG-mediated recombination, which specifically targets genes and regulatory elements active during B cell differentiation, as the underlying mechanism.

KW - Core Binding Factor Alpha 2 Subunit/genetics

KW - Gene Expression Regulation, Neoplastic/genetics

KW - Gene Rearrangement/genetics

KW - Genetic Variation

KW - Homeodomain Proteins/genetics

KW - Humans

KW - Oncogene Proteins, Fusion/genetics

KW - Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics

KW - Recombination, Genetic/genetics

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DO - 10.1038/ng.2879

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A RAG driver on the road to pediatric ALL

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