A road map for the treatment of pediatric diffuse midline glioma

ChadTough meeting group

doi:10.1016/j.ccell.2023.11.002

A road map for the treatment of pediatric diffuse midline glioma

ChadTough meeting group

Group Hulleman

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

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Recent clinical trials for H3K27-altered diffuse midline gliomas (DMGs) have shown much promise. We present a consensus roadmap and identify three major barriers: (1) refinement of experimental models to include immune and brain-specific components; (2) collaboration among researchers, clinicians, and industry to integrate patient-derived data through sharing, transparency, and regulatory considerations; and (3) streamlining clinical efforts including biopsy, CNS-drug delivery, endpoint determination, and response monitoring. We highlight the importance of comprehensive collaboration to advance the understanding, diagnostics, and therapeutics for DMGs.

Originele taal-2	Engels
Pagina's (van-tot)	1-5
Aantal pagina's	5
Tijdschrift	Cancer Cell
Volume	42
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1016/j.ccell.2023.11.002
Status	Gepubliceerd - 30 nov. 2023

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10.1016/j.ccell.2023.11.002

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title = "A road map for the treatment of pediatric diffuse midline glioma",

abstract = "Recent clinical trials for H3K27-altered diffuse midline gliomas (DMGs) have shown much promise. We present a consensus roadmap and identify three major barriers: (1) refinement of experimental models to include immune and brain-specific components; (2) collaboration among researchers, clinicians, and industry to integrate patient-derived data through sharing, transparency, and regulatory considerations; and (3) streamlining clinical efforts including biopsy, CNS-drug delivery, endpoint determination, and response monitoring. We highlight the importance of comprehensive collaboration to advance the understanding, diagnostics, and therapeutics for DMGs.",

keywords = "Humans, Child, Brain Neoplasms/genetics, Glioma/diagnosis, Mutation, Brain/pathology, Biopsy",

author = "{ChadTough meeting group} and Carl Koschmann and Al-Holou, {Wajd N} and Alonso, {Marta M} and Jamie Anastas and Pratiti Bandopadhayay and Tara Barron and Oren Becher and Rodrigo Cartaxo and Castro, {Maria G} and Chan Chung and Madison Clausen and Derek Dang and Robert Doherty and Ryan Duchatel and Matthew Dun and Mariella Filbin and Andrea Franson and Stefanie Galban and {Garcia Moure}, Marc and Hugh Garton and Pruthvi Gowda and Marques, {Joana Graca} and Cynthia Hawkins and Allison Heath and Esther Hulleman and Sunjong Ji and Chris Jones and Lindsay Kilburn and Cassie Kline and Koldobskiy, {Michael A} and Daniel Lim and Lowenstein, {Pedro R} and Lu, {Q Richard} and Joanna Lum and Stephen Mack and Suresh Magge and Bernard Marini and Donna Martin and Neena Marupudi and Dana Messinger and Rajen Mody and Meredith Morgan and Mateus Mota and Karin Muraszko and Sabine Mueller and Natarajan, {Siva Kumar} and Javad Nazarian and Michael Niculcea and Nicholas Nuechterlein and Hideho Okada",

year = "2023",

month = nov,

day = "30",

doi = "10.1016/j.ccell.2023.11.002",

language = "English",

volume = "42",

pages = "1--5",

journal = "Cancer Cell",

issn = "1535-6108",

publisher = "Cell Press",

number = "1",

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AU - ChadTough meeting group

AU - Koschmann, Carl

AU - Al-Holou, Wajd N

AU - Alonso, Marta M

AU - Anastas, Jamie

AU - Bandopadhayay, Pratiti

AU - Barron, Tara

AU - Becher, Oren

AU - Cartaxo, Rodrigo

AU - Castro, Maria G

AU - Chung, Chan

AU - Clausen, Madison

AU - Dang, Derek

AU - Doherty, Robert

AU - Duchatel, Ryan

AU - Dun, Matthew

AU - Filbin, Mariella

AU - Franson, Andrea

AU - Galban, Stefanie

AU - Garcia Moure, Marc

AU - Garton, Hugh

AU - Gowda, Pruthvi

AU - Marques, Joana Graca

AU - Hawkins, Cynthia

AU - Heath, Allison

AU - Hulleman, Esther

AU - Ji, Sunjong

AU - Jones, Chris

AU - Kilburn, Lindsay

AU - Kline, Cassie

AU - Koldobskiy, Michael A

AU - Lim, Daniel

AU - Lowenstein, Pedro R

AU - Lu, Q Richard

AU - Lum, Joanna

AU - Mack, Stephen

AU - Magge, Suresh

AU - Marini, Bernard

AU - Martin, Donna

AU - Marupudi, Neena

AU - Messinger, Dana

AU - Mody, Rajen

AU - Morgan, Meredith

AU - Mota, Mateus

AU - Muraszko, Karin

AU - Mueller, Sabine

AU - Natarajan, Siva Kumar

AU - Nazarian, Javad

AU - Niculcea, Michael

AU - Nuechterlein, Nicholas

AU - Okada, Hideho

PY - 2023/11/30

Y1 - 2023/11/30

N2 - Recent clinical trials for H3K27-altered diffuse midline gliomas (DMGs) have shown much promise. We present a consensus roadmap and identify three major barriers: (1) refinement of experimental models to include immune and brain-specific components; (2) collaboration among researchers, clinicians, and industry to integrate patient-derived data through sharing, transparency, and regulatory considerations; and (3) streamlining clinical efforts including biopsy, CNS-drug delivery, endpoint determination, and response monitoring. We highlight the importance of comprehensive collaboration to advance the understanding, diagnostics, and therapeutics for DMGs.

AB - Recent clinical trials for H3K27-altered diffuse midline gliomas (DMGs) have shown much promise. We present a consensus roadmap and identify three major barriers: (1) refinement of experimental models to include immune and brain-specific components; (2) collaboration among researchers, clinicians, and industry to integrate patient-derived data through sharing, transparency, and regulatory considerations; and (3) streamlining clinical efforts including biopsy, CNS-drug delivery, endpoint determination, and response monitoring. We highlight the importance of comprehensive collaboration to advance the understanding, diagnostics, and therapeutics for DMGs.

KW - Humans

KW - Child

KW - Brain Neoplasms/genetics

KW - Glioma/diagnosis

KW - Mutation

KW - Brain/pathology

KW - Biopsy

U2 - 10.1016/j.ccell.2023.11.002

DO - 10.1016/j.ccell.2023.11.002

M3 - Article

C2 - 38039965

SN - 1535-6108

VL - 42

SP - 1

EP - 5

JO - Cancer Cell

JF - Cancer Cell

IS - 1

ER -

A road map for the treatment of pediatric diffuse midline glioma

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