A Role of brachytherapy in bilateral Wilms tumors: A long-term follow-up of three highly selected cases and literature review

Raquel Dávila Fajardo, Bradley R Pieters, Jim C H Wilde, Hugo A Heij, Rafal Chrzan, Godelieve Tytgat, Annelies M C Mavinkurve-Groothuis, Anne Smets, Petra S Kroon, An Van Damme, Kees P van de Ven, Ronald R de Krijger, Marc R Lilien, Marc H Wijnen, Marry M van den Heuvel-Eibrink, Geert O Janssens

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

Samenvatting

PURPOSE: To describe experience with partial nephrectomy combined with brachytherapy as part of the local management of bilateral Wilms tumor (WT) including a review of the available literature.

RESULTS (METHODS AND CASE DESCRIPTION): Between 2011 and 2014, three highly selected patients (age nine months, 16 months, and 4 years) with bilateral WT (two synchronous and one metachronous) underwent enucleation and perioperative brachytherapy to the tumor bed. With a minimum follow-up of 5 years, all three patients are in continuous complete remission with preserved kidney function.

CONCLUSIONS: Although nephron sparing surgery aiming at tumor free-margins remains the gold standard for bilateral WT, tumor enucleation followed by brachytherapy may be considered in carefully selected patients at high risk for end-stage kidney failure. Given the rarity and complexity of the procedure, concentration of care of such patients is mandatory.

Originele taal-2Engels
Pagina's (van-tot)478-484
Aantal pagina's7
TijdschriftBrachytherapy
Volume20
Nummer van het tijdschrift2
DOI's
StatusGepubliceerd - dec. 2020

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