A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

Nicole Almanzar, Jane Antony, Ankit S. Baghel, Isaac Bakerman, Ishita Bansal, Ben A. Barres, Philip A. Beachy, Daniela Berdnik, Biter Bilen, Douglas Brownfield, Corey Cain, Charles K.F. Chan, Michelle B. Chen, Michael F. Clarke, Spyros Darmanis, Stephanie D. Conley, Aaron Demers, Kubilay Demir, Antoine de Morree, Tessa DivitaHaley du Bois, Hamid Ebadi, F. Hernán Espinoza, Matt Fish, Qiang Gan, Benson M. George, Astrid Gillich, Rafael Gòmez-Sjöberg, Foad Green, Geraldine Genetiano, Xueying Gu, Gunsagar S. Gulati, Oliver Hahn, Michael Seamus Haney, Yan Hang, Lincoln Harris, Mu He, Shayan Hosseinzadeh, Albin Huang, Kerwyn Casey Huang, Tal Iram, Taichi Isobe, Feather Ives, Robert C C. Jones, Kevin S. Kao, Jim Karkanias, Guruswamy Karnam, Andreas Keller, Aaron M. Kershner, Weng Chuan Peng

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

Samenvatting

Ageing is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death1. Despite rapid advances over recent years, many of the molecular and cellular processes that underlie the progressive loss of healthy physiology are poorly understood2. To gain a better insight into these processes, here we generate a single-cell transcriptomic atlas across the lifespan of Mus musculus that includes data from 23 tissues and organs. We found cell-specific changes occurring across multiple cell types and organs, as well as age-related changes in the cellular composition of different organs. Using single-cell transcriptomic data, we assessed cell-type-specific manifestations of different hallmarks of ageing—such as senescence3, genomic instability4 and changes in the immune system2. This transcriptomic atlas—which we denote Tabula Muris Senis, or ‘Mouse Ageing Cell Atlas’—provides molecular information about how the most important hallmarks of ageing are reflected in a broad range of tissues and cell types.
Originele taal-2Engels
Pagina's (van-tot)590-595
Aantal pagina's6
TijdschriftNature
Volume583
Nummer van het tijdschrift7817
DOI's
StatusGepubliceerd - 23 jul. 2020

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