A twenty-year review of diagnosing and treating children with diffuse intrinsic pontine glioma in The Netherlands

Sophie E M Veldhuijzen van Zanten; Marc H A Jansen; Esther Sanchez Aliaga; Dannis G van Vuurden; W Peter Vandertop; Gertjan J L Kaspers

doi:10.1586/14737140.2015.974563

A twenty-year review of diagnosing and treating children with diffuse intrinsic pontine glioma in The Netherlands

Sophie E M Veldhuijzen van Zanten, Marc H A Jansen, Esther Sanchez Aliaga, Dannis G van Vuurden, W Peter Vandertop, Gertjan J L Kaspers

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

41 Citaten (Scopus)

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INTRODUCTION: Children with diffuse intrinsic pontine glioma (DIPG) face a dismal prognosis, with a median overall survival of 9 months. Our aims are to determine the incidence of DIPG in the Netherlands and to identify points for improvement in clinical research, a prerequisite for increasing the chance to find a cure.

METHODS: We performed a population-based retrospective cohort study by evaluating all children diagnosed with DIPG in the Netherlands between 1990 and 2010.

RESULTS: The incidence of DIPG in the Netherlands corresponds with international literature. Between 1990 and 2010, a large heterogeneity of treatment schedules was applied and only a minority of patients was included in clinical trials.

DISCUSSION: Given the rarity of DIPG, we emphasize the need for (inter-)national trials to facilitate the identification of potentially effective therapeutics in the future. This can be supported by the recent development of a European DIPG registry enabling international study collaborations.

Originele taal-2	Engels
Pagina's (van-tot)	157-64
Aantal pagina's	8
Tijdschrift	Expert review of anticancer therapy
Volume	15
Nummer van het tijdschrift	2
DOI's	https://doi.org/10.1586/14737140.2015.974563
Status	Gepubliceerd - feb. 2015
Extern gepubliceerd	Ja

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10.1586/14737140.2015.974563

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title = "A twenty-year review of diagnosing and treating children with diffuse intrinsic pontine glioma in The Netherlands",

abstract = "INTRODUCTION: Children with diffuse intrinsic pontine glioma (DIPG) face a dismal prognosis, with a median overall survival of 9 months. Our aims are to determine the incidence of DIPG in the Netherlands and to identify points for improvement in clinical research, a prerequisite for increasing the chance to find a cure.METHODS: We performed a population-based retrospective cohort study by evaluating all children diagnosed with DIPG in the Netherlands between 1990 and 2010.RESULTS: The incidence of DIPG in the Netherlands corresponds with international literature. Between 1990 and 2010, a large heterogeneity of treatment schedules was applied and only a minority of patients was included in clinical trials.DISCUSSION: Given the rarity of DIPG, we emphasize the need for (inter-)national trials to facilitate the identification of potentially effective therapeutics in the future. This can be supported by the recent development of a European DIPG registry enabling international study collaborations.",

keywords = "Brain Stem Neoplasms/diagnosis, Child, Child, Preschool, Cohort Studies, Female, Glioma/diagnosis, Humans, Male, Netherlands, Pons/pathology, Prognosis, Retrospective Studies, Survival Rate",

author = "{Veldhuijzen van Zanten}, {Sophie E M} and Jansen, {Marc H A} and {Sanchez Aliaga}, Esther and {van Vuurden}, {Dannis G} and Vandertop, {W Peter} and Kaspers, {Gertjan J L}",

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doi = "10.1586/14737140.2015.974563",

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AU - Veldhuijzen van Zanten, Sophie E M

AU - Jansen, Marc H A

AU - Sanchez Aliaga, Esther

AU - van Vuurden, Dannis G

AU - Vandertop, W Peter

AU - Kaspers, Gertjan J L

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N2 - INTRODUCTION: Children with diffuse intrinsic pontine glioma (DIPG) face a dismal prognosis, with a median overall survival of 9 months. Our aims are to determine the incidence of DIPG in the Netherlands and to identify points for improvement in clinical research, a prerequisite for increasing the chance to find a cure.METHODS: We performed a population-based retrospective cohort study by evaluating all children diagnosed with DIPG in the Netherlands between 1990 and 2010.RESULTS: The incidence of DIPG in the Netherlands corresponds with international literature. Between 1990 and 2010, a large heterogeneity of treatment schedules was applied and only a minority of patients was included in clinical trials.DISCUSSION: Given the rarity of DIPG, we emphasize the need for (inter-)national trials to facilitate the identification of potentially effective therapeutics in the future. This can be supported by the recent development of a European DIPG registry enabling international study collaborations.

AB - INTRODUCTION: Children with diffuse intrinsic pontine glioma (DIPG) face a dismal prognosis, with a median overall survival of 9 months. Our aims are to determine the incidence of DIPG in the Netherlands and to identify points for improvement in clinical research, a prerequisite for increasing the chance to find a cure.METHODS: We performed a population-based retrospective cohort study by evaluating all children diagnosed with DIPG in the Netherlands between 1990 and 2010.RESULTS: The incidence of DIPG in the Netherlands corresponds with international literature. Between 1990 and 2010, a large heterogeneity of treatment schedules was applied and only a minority of patients was included in clinical trials.DISCUSSION: Given the rarity of DIPG, we emphasize the need for (inter-)national trials to facilitate the identification of potentially effective therapeutics in the future. This can be supported by the recent development of a European DIPG registry enabling international study collaborations.

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KW - Glioma/diagnosis

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KW - Netherlands

KW - Pons/pathology

KW - Prognosis

KW - Retrospective Studies

KW - Survival Rate

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A twenty-year review of diagnosing and treating children with diffuse intrinsic pontine glioma in The Netherlands

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