Abdominosacral resection for locally advanced and recurrent rectal cancer

F. T.J. Ferenschild, M. Vermaas, C. Verhoef, R. S. Dwarkasing, A. M.M. Eggermont, J. H.W. De Wilt

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

42 Citaten (Scopus)


Background: The results of resection of locally advanced and recurrent rectal cancers, including sacral resection, were analysed critically. Methods: Between 1987 and 2007, 353 patients with locally advanced or recurrent rectal cancer, all treated in a tertiary referral centre, were identified from a prospective database. Twenty-five patients (eight primary and 17 recurrent tumours) underwent en bloc sacral resection. Results: A mid-sacral resection was carried out in 12 patients (level S3) and a low sacral resection in 13 (level S4/S5). Nineteen patients had an R0, four an R1 and two an R2 resection. There was no postoperative mortality. Median follow-up was 32 months. Incomplete resection had an independent negative influence on local control (5-year local recurrence rate 42 versus 0 per cent in those with and without incomplete resection; P < 0.001). The 5-year overall survival rate was 30 per cent. Five patients with recurrent tumour had pathological invasion into the sacral bone and none survived beyond 1 year. Conclusion: Abdominosacral resection can be performed in patients with locally advanced and recurrent rectal cancer. Patients who cannot undergo a complete resection or have clear evidence of cortical invasion have a poor prognosis.

Originele taal-2Engels
Pagina's (van-tot)1341-1347
Aantal pagina's7
TijdschriftBritish Journal of Surgery
Nummer van het tijdschrift11
StatusGepubliceerd - nov. 2009
Extern gepubliceerdJa


Duik in de onderzoeksthema's van 'Abdominosacral resection for locally advanced and recurrent rectal cancer'. Samen vormen ze een unieke vingerafdruk.

Citeer dit