Adoptive cellular immunotherapy for refractory childhood cancers: a single center experience

Michael Merker, Michael Torsten Meister, Annekathrin Heinze, Andrea Jarisch, Jan Sörensen, Sabine Huenecke, Melanie Bremm, Claudia Cappel, Thomas Klingebiel, Peter Bader, Eva Rettinger

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

Samenvatting

Prognosis of refractory childhood cancers despite multimodal treatment strategies remains poor. Here, we report a single center experience encountered in 18 patients with refractory solid malignancies treated with adoptive cellular immunotherapy (ACI) from haploidentical or matched donors following hematopoietic stem cell transplantation. While seven patients were in partial and six in complete remission (CR), five patients suffered from relapsed diseases at the time of ACI. 1.5-year probabilities of overall survival (OS) and progression-free survival (PFS) were 19.5% and 16.1% for all patients. Patients in CR showed estimated 1.5-year OS and PFS of 50.1% and 42.7%, respectively. CR was induced or rather sustained in ten children, with two still being alive 9.6 and 9.3 years after ACI. Naïve, central and effector memory T-cells correlated with responses. However, the majority of patients relapsed. Cumulative incidence of relapse was 79.8% at 1.5 years. Acute graft versus host disease (aGVHD) occurred in nine of 18 patients (50%) with aGVHD grade I-II observed in six (33%) and aGVHD grade III seen in three (17%) patients, manageable in all cases. Altogether, study results indicate that donor-derived ACI at its current state offers palliation but no clear curative benefit for refractory childhood cancers and warrants further improvement.

Originele taal-2Engels
Pagina's (van-tot)6138-6151
Aantal pagina's14
TijdschriftOncotarget
Volume10
Nummer van het tijdschrift58
DOI's
StatusGepubliceerd - 22 okt. 2019
Extern gepubliceerdJa

Vingerafdruk

Duik in de onderzoeksthema's van 'Adoptive cellular immunotherapy for refractory childhood cancers: a single center experience'. Samen vormen ze een unieke vingerafdruk.

Citeer dit