TY - JOUR
T1 - Advances in molecular markers of germ cell cancer in patients with disorders of sex development
AU - van der Zwan, Yvonne G
AU - Cools, Martine
AU - Looijenga, Leendert H J
N1 - © 2014 S. Karger AG, Basel.
PY - 2014
Y1 - 2014
N2 - The risk of malignant transformation of germ cells, leading to germ cell cancer (GCC) in patients with disorders of sex development, is highly heterogeneous and dependent on a number of parameters, of which the presence of Y-chromosomal material is essential. This chapter describes the networks, both protein-coding and regulatory processes, related to normal gonadal development and GCC, with focus on recent advances of molecular markers for early diagnosis.
AB - The risk of malignant transformation of germ cells, leading to germ cell cancer (GCC) in patients with disorders of sex development, is highly heterogeneous and dependent on a number of parameters, of which the presence of Y-chromosomal material is essential. This chapter describes the networks, both protein-coding and regulatory processes, related to normal gonadal development and GCC, with focus on recent advances of molecular markers for early diagnosis.
KW - Biomarkers, Tumor/genetics
KW - Disorders of Sex Development/complications
KW - Humans
KW - Neoplasms, Germ Cell and Embryonal/complications
KW - Sex Determination Processes/physiology
U2 - 10.1159/000363641
DO - 10.1159/000363641
M3 - Review article
C2 - 25247654
SN - 1421-7082
VL - 27
SP - 172
EP - 184
JO - Endocrine development
JF - Endocrine development
ER -