Aging and genome maintenance: Lessons from the mouse?

Paul Hasty; Judith Campisi; Jan Hoeijmakers; Harry Van Steeg; Jan Vijg

doi:10.1126/science.1079161

Aging and genome maintenance: Lessons from the mouse?

Paul Hasty, Judith Campisi, Jan Hoeijmakers, Harry Van Steeg, Jan Vijg

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › peer review

492 Citaten (Scopus)

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Recent progress in the science of aging is driven largely by the use of model systems, ranging from yeast and nematodes to mice. These models have revealed conservation in genetic pathways that balance energy production and its damaging byproducts with pathways that preserve somatic maintenance. Maintaining genome integrity has emerged as a major factor in longevity and cell viability. Here we discuss the use of mouse models with defects in genome maintenance for understanding the molecular basis of aging in humans.

Originele taal-2	Engels
Pagina's (van-tot)	1355-1359
Aantal pagina's	5
Tijdschrift	Science
Volume	299
Nummer van het tijdschrift	5611
DOI's	https://doi.org/10.1126/science.1079161
Status	Gepubliceerd - 28 feb. 2003
Extern gepubliceerd	Ja

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title = "Aging and genome maintenance: Lessons from the mouse?",

abstract = "Recent progress in the science of aging is driven largely by the use of model systems, ranging from yeast and nematodes to mice. These models have revealed conservation in genetic pathways that balance energy production and its damaging byproducts with pathways that preserve somatic maintenance. Maintaining genome integrity has emerged as a major factor in longevity and cell viability. Here we discuss the use of mouse models with defects in genome maintenance for understanding the molecular basis of aging in humans.",

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Aging and genome maintenance: Lessons from the mouse?

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