Aging and genome maintenance: Lessons from the mouse?

Paul Hasty, Judith Campisi, Jan Hoeijmakers, Harry Van Steeg, Jan Vijg

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

490 Citaten (Scopus)

Samenvatting

Recent progress in the science of aging is driven largely by the use of model systems, ranging from yeast and nematodes to mice. These models have revealed conservation in genetic pathways that balance energy production and its damaging byproducts with pathways that preserve somatic maintenance. Maintaining genome integrity has emerged as a major factor in longevity and cell viability. Here we discuss the use of mouse models with defects in genome maintenance for understanding the molecular basis of aging in humans.

Originele taal-2Engels
Pagina's (van-tot)1355-1359
Aantal pagina's5
TijdschriftScience
Volume299
Nummer van het tijdschrift5611
DOI's
StatusGepubliceerd - 28 feb. 2003
Extern gepubliceerdJa

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