An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas

Paul Roepman; Lodewyk F.A. Wessels; Nienke Kettelarij; Patrick Kemmeren; Antony J. Miles; Philip Lijnzaad; Marcel G.J. Tilanus; Ronald Koole; Gert Jan Hordijk; Peter C. Van Der Vliet; Marcel J.T. Reinders; Piet J. Slootweg; Frank C.P. Holstege

doi:10.1038/ng1502

An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas

Paul Roepman, Lodewyk F.A. Wessels, Nienke Kettelarij, Patrick Kemmeren, Antony J. Miles, Philip Lijnzaad, Marcel G.J. Tilanus, Ronald Koole, Gert Jan Hordijk, Peter C. Van Der Vliet, Marcel J.T. Reinders, Piet J. Slootweg, Frank C.P. Holstege

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

355 Citaten (Scopus)

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Metastasis is the process by which cancers spread to distinct sites in the body. It is the principal cause of death in individuals suffering from cancer. For some types of cancer, early detection of metastasis at lymph nodes close to the site of the primary tumor is pivotal for appropriate treatment. Because it can be difficult to detect lymph node metastases reliably, many individuals currently receive inappropriate treatment. We show here that DNA microarray gene-expression profiling can detect lymph node metastases for primary head and neck squamous cell carcinomas that arise in the oral cavity and oropharynx. The predictor, established with an 82-tumor training set, outperforms current clinical diagnosis when independently validated. The 102 predictor genes offer unique insights into the processes underlying metastasis. The results show that the metastatic state can be deciphered from the primary tumor gene-expression pattern and that treatment can be substantially improved.

Originele taal-2	Engels
Pagina's (van-tot)	182-186
Aantal pagina's	5
Tijdschrift	Nature Genetics
Volume	37
Nummer van het tijdschrift	2
DOI's	https://doi.org/10.1038/ng1502
Status	Gepubliceerd - feb. 2005
Extern gepubliceerd	Ja

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Roepman, P., Wessels, L. F. A., Kettelarij, N., Kemmeren, P., Miles, A. J., Lijnzaad, P., Tilanus, M. G. J., Koole, R., Hordijk, G. J., Van Der Vliet, P. C., Reinders, M. J. T., Slootweg, P. J., & Holstege, F. C. P. (2005). An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas. Nature Genetics, 37(2), 182-186. https://doi.org/10.1038/ng1502

@article{f32fe5df1025499aac7f69b0acf4c3ab,

title = "An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas",

abstract = "Metastasis is the process by which cancers spread to distinct sites in the body. It is the principal cause of death in individuals suffering from cancer. For some types of cancer, early detection of metastasis at lymph nodes close to the site of the primary tumor is pivotal for appropriate treatment. Because it can be difficult to detect lymph node metastases reliably, many individuals currently receive inappropriate treatment. We show here that DNA microarray gene-expression profiling can detect lymph node metastases for primary head and neck squamous cell carcinomas that arise in the oral cavity and oropharynx. The predictor, established with an 82-tumor training set, outperforms current clinical diagnosis when independently validated. The 102 predictor genes offer unique insights into the processes underlying metastasis. The results show that the metastatic state can be deciphered from the primary tumor gene-expression pattern and that treatment can be substantially improved.",

author = "Paul Roepman and Wessels, {Lodewyk F.A.} and Nienke Kettelarij and Patrick Kemmeren and Miles, {Antony J.} and Philip Lijnzaad and Tilanus, {Marcel G.J.} and Ronald Koole and Hordijk, {Gert Jan} and {Van Der Vliet}, {Peter C.} and Reinders, {Marcel J.T.} and Slootweg, {Piet J.} and Holstege, {Frank C.P.}",

note = "Funding Information: We thank D. van Leenen, M. Groot-Koerkamp and J. van Helvoort for microarray production and technology optimization; M. Verdaasdonk for assistance with biopsies; A. Leijen for computer assistance and J. van de Peppel for advice and discussion. Work in the group of F.C.P.H. is supported by grants from the Netherlands Organization for Scientific Research and by the European Union fifth framework project TEMBLOR.",

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Roepman, P, Wessels, LFA, Kettelarij, N, Kemmeren, P, Miles, AJ, Lijnzaad, P, Tilanus, MGJ, Koole, R, Hordijk, GJ, Van Der Vliet, PC, Reinders, MJT, Slootweg, PJ & Holstege, FCP 2005, 'An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas', Nature Genetics, vol. 37, nr. 2, blz. 182-186. https://doi.org/10.1038/ng1502

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AU - Van Der Vliet, Peter C.

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AU - Slootweg, Piet J.

AU - Holstege, Frank C.P.

N1 - Funding Information: We thank D. van Leenen, M. Groot-Koerkamp and J. van Helvoort for microarray production and technology optimization; M. Verdaasdonk for assistance with biopsies; A. Leijen for computer assistance and J. van de Peppel for advice and discussion. Work in the group of F.C.P.H. is supported by grants from the Netherlands Organization for Scientific Research and by the European Union fifth framework project TEMBLOR.

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N2 - Metastasis is the process by which cancers spread to distinct sites in the body. It is the principal cause of death in individuals suffering from cancer. For some types of cancer, early detection of metastasis at lymph nodes close to the site of the primary tumor is pivotal for appropriate treatment. Because it can be difficult to detect lymph node metastases reliably, many individuals currently receive inappropriate treatment. We show here that DNA microarray gene-expression profiling can detect lymph node metastases for primary head and neck squamous cell carcinomas that arise in the oral cavity and oropharynx. The predictor, established with an 82-tumor training set, outperforms current clinical diagnosis when independently validated. The 102 predictor genes offer unique insights into the processes underlying metastasis. The results show that the metastatic state can be deciphered from the primary tumor gene-expression pattern and that treatment can be substantially improved.

AB - Metastasis is the process by which cancers spread to distinct sites in the body. It is the principal cause of death in individuals suffering from cancer. For some types of cancer, early detection of metastasis at lymph nodes close to the site of the primary tumor is pivotal for appropriate treatment. Because it can be difficult to detect lymph node metastases reliably, many individuals currently receive inappropriate treatment. We show here that DNA microarray gene-expression profiling can detect lymph node metastases for primary head and neck squamous cell carcinomas that arise in the oral cavity and oropharynx. The predictor, established with an 82-tumor training set, outperforms current clinical diagnosis when independently validated. The 102 predictor genes offer unique insights into the processes underlying metastasis. The results show that the metastatic state can be deciphered from the primary tumor gene-expression pattern and that treatment can be substantially improved.

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An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas

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