An Overview of Liver Directed Locoregional Therapies

Diederik J. Höppener; Dirk J. Grünhagen; Alexander M.M. Eggermont; Astrid A.M. van der Veldt; Cornelis Verhoef

doi:10.1016/j.soc.2020.09.001

An Overview of Liver Directed Locoregional Therapies

Diederik J. Höppener, Dirk J. Grünhagen, Alexander M.M. Eggermont, Astrid A.M. van der Veldt, Cornelis Verhoef

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Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › peer review

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An overview of all liver-directed locoregional therapies, including surgical resection for melanoma liver metastases (MLMs), is provided. MLM patients are divided by their primary melanoma location; cutaneous, uvea (eye), and mucosal melanoma. If patients with isolated cutaneous MLMs are considered for surgical resection, treatment with systemic therapy should be part of the treatment course. For uveal MLMs, complete surgical or ablative treatment of all MLMs suggests superior results compared with other liver-directed or systemic therapies, based on current evidence, no recommendations for any liver-directed regional therapy in the treatment of mucosal MLMs can be made.

Originele taal-2	Engels
Pagina's (van-tot)	103-123
Aantal pagina's	21
Tijdschrift	Surgical Oncology Clinics of North America
Volume	30
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1016/j.soc.2020.09.001
Status	Gepubliceerd - jan. 2021

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10.1016/j.soc.2020.09.001

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title = "An Overview of Liver Directed Locoregional Therapies",

abstract = "An overview of all liver-directed locoregional therapies, including surgical resection for melanoma liver metastases (MLMs), is provided. MLM patients are divided by their primary melanoma location; cutaneous, uvea (eye), and mucosal melanoma. If patients with isolated cutaneous MLMs are considered for surgical resection, treatment with systemic therapy should be part of the treatment course. For uveal MLMs, complete surgical or ablative treatment of all MLMs suggests superior results compared with other liver-directed or systemic therapies, based on current evidence, no recommendations for any liver-directed regional therapy in the treatment of mucosal MLMs can be made.",

keywords = "Cutaneous melanoma, Liver directed therapy, Liver metastasis, Local therapy, Mucosal melanoma, Surgery, Systematic review, Uveal melanoma",

author = "H{\"o}ppener, {Diederik J.} and Gr{\"u}nhagen, {Dirk J.} and Eggermont, {Alexander M.M.} and {van der Veldt}, {Astrid A.M.} and Cornelis Verhoef",

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year = "2021",

month = jan,

doi = "10.1016/j.soc.2020.09.001",

language = "English",

volume = "30",

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AU - Eggermont, Alexander M.M.

AU - van der Veldt, Astrid A.M.

AU - Verhoef, Cornelis

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AB - An overview of all liver-directed locoregional therapies, including surgical resection for melanoma liver metastases (MLMs), is provided. MLM patients are divided by their primary melanoma location; cutaneous, uvea (eye), and mucosal melanoma. If patients with isolated cutaneous MLMs are considered for surgical resection, treatment with systemic therapy should be part of the treatment course. For uveal MLMs, complete surgical or ablative treatment of all MLMs suggests superior results compared with other liver-directed or systemic therapies, based on current evidence, no recommendations for any liver-directed regional therapy in the treatment of mucosal MLMs can be made.

KW - Cutaneous melanoma

KW - Liver directed therapy

KW - Liver metastasis

KW - Local therapy

KW - Mucosal melanoma

KW - Surgery

KW - Systematic review

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An Overview of Liver Directed Locoregional Therapies

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