APC, signal transduction and genetic instability in colorectal cancer

Riccardo Fodde, Ron Smits, Hans Clevers

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

766 Citaten (Scopus)


Colorectal cancer arises through a gradual series of histological changes, each of which is accompanied by a specific genetic alteration. In general, an intestinal cell needs to comply with two essential requirements to develop into a cancer: it must acquire selective advantage to allow for the initial clonal expansion, and genetic instability to allow for multiple hits in other genes that are responsible for tumour progression and malignant transformation. Inactivation of APC - the gene responsible for most cases of colorectal cancer - might fulfil both requirements.

Originele taal-2Engels
Pagina's (van-tot)55-67
Aantal pagina's13
TijdschriftNature Reviews Cancer
Nummer van het tijdschrift1
StatusGepubliceerd - 2001
Extern gepubliceerdJa


Duik in de onderzoeksthema's van 'APC, signal transduction and genetic instability in colorectal cancer'. Samen vormen ze een unieke vingerafdruk.

Citeer dit