Application of antisense technology to therapeutics

O Heidenreich; S H Kang; X Xu; M Nerenberg

doi:10.1016/s1357-4310(95)80090-5

Application of antisense technology to therapeutics

O Heidenreich, S H Kang, X Xu, M Nerenberg

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › peer review

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Antisense oligonucleotides inhibit gene expression by binding in a sequence-specific manner to an RNA target. Modern nucleotide chemistry has enabled the synthesis of chemically modified oligonucleotides that are highly resistant to nuclease degradation. Among other applications, these agents are currently being evaluated as potential antiviral and anticancer drugs. However, several unsolved problems remain. Poor efficiency of delivery to cells, tissue toxicity and antisense-independent biological effects of oligonucleotides currently limit the widespread application of antisense oligonucleotides to human disease. This article reviews some of the applications of antisense oligonucleotides and discusses problems associated with these applications.

Originele taal-2	Engels
Pagina's (van-tot)	128-33
Aantal pagina's	6
Tijdschrift	Molecular medicine today
Volume	1
Nummer van het tijdschrift	3
DOI's	https://doi.org/10.1016/s1357-4310(95)80090-5
Status	Gepubliceerd - jun. 1995
Extern gepubliceerd	Ja

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title = "Application of antisense technology to therapeutics",

abstract = "Antisense oligonucleotides inhibit gene expression by binding in a sequence-specific manner to an RNA target. Modern nucleotide chemistry has enabled the synthesis of chemically modified oligonucleotides that are highly resistant to nuclease degradation. Among other applications, these agents are currently being evaluated as potential antiviral and anticancer drugs. However, several unsolved problems remain. Poor efficiency of delivery to cells, tissue toxicity and antisense-independent biological effects of oligonucleotides currently limit the widespread application of antisense oligonucleotides to human disease. This article reviews some of the applications of antisense oligonucleotides and discusses problems associated with these applications.",

keywords = "Animals, Anti-HIV Agents/pharmacology, Drug Carriers, Gene Expression Regulation/drug effects, HIV-1/drug effects, Humans, Mammals, Oligonucleotides, Antisense/chemistry, Thionucleotides/chemistry",

author = "O Heidenreich and Kang, {S H} and X Xu and M Nerenberg",

year = "1995",

month = jun,

doi = "10.1016/s1357-4310(95)80090-5",

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AU - Heidenreich, O

AU - Kang, S H

AU - Xu, X

AU - Nerenberg, M

PY - 1995/6

Y1 - 1995/6

N2 - Antisense oligonucleotides inhibit gene expression by binding in a sequence-specific manner to an RNA target. Modern nucleotide chemistry has enabled the synthesis of chemically modified oligonucleotides that are highly resistant to nuclease degradation. Among other applications, these agents are currently being evaluated as potential antiviral and anticancer drugs. However, several unsolved problems remain. Poor efficiency of delivery to cells, tissue toxicity and antisense-independent biological effects of oligonucleotides currently limit the widespread application of antisense oligonucleotides to human disease. This article reviews some of the applications of antisense oligonucleotides and discusses problems associated with these applications.

AB - Antisense oligonucleotides inhibit gene expression by binding in a sequence-specific manner to an RNA target. Modern nucleotide chemistry has enabled the synthesis of chemically modified oligonucleotides that are highly resistant to nuclease degradation. Among other applications, these agents are currently being evaluated as potential antiviral and anticancer drugs. However, several unsolved problems remain. Poor efficiency of delivery to cells, tissue toxicity and antisense-independent biological effects of oligonucleotides currently limit the widespread application of antisense oligonucleotides to human disease. This article reviews some of the applications of antisense oligonucleotides and discusses problems associated with these applications.

KW - Animals

KW - Anti-HIV Agents/pharmacology

KW - Drug Carriers

KW - Gene Expression Regulation/drug effects

KW - HIV-1/drug effects

KW - Humans

KW - Mammals

KW - Oligonucleotides, Antisense/chemistry

KW - Thionucleotides/chemistry

U2 - 10.1016/s1357-4310(95)80090-5

DO - 10.1016/s1357-4310(95)80090-5

M3 - Review article

C2 - 9415148

SN - 1357-4310

VL - 1

SP - 128

EP - 133

JO - Molecular medicine today

JF - Molecular medicine today

IS - 3

ER -

Application of antisense technology to therapeutics

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