Samenvatting
Wnt signalling results in transcriptional stimulation of genes controlling normal and malignant development. A key effector of the canonical Wnt pathway is β-catenin (also known as Drosophila melanogaster Armadillo (Arm)), thought to function as a nuclear co-activator of TCF transcription factors. This has been challenged by unexpected observations of membrane-bound Arm/β-catenin signalling activity. Plausible explanations allow these observations to be reconciled with the large body of evidence supporting a nuclear function of Arm/β-catenin.
Originele taal-2 | Engels |
---|---|
Pagina's (van-tot) | 179-182 |
Aantal pagina's | 4 |
Tijdschrift | Nature Cell Biology |
Volume | 5 |
Nummer van het tijdschrift | 3 |
DOI's | |
Status | Gepubliceerd - 1 mrt. 2003 |
Extern gepubliceerd | Ja |