@article{59219a456bc14f65bf57709a7fb5a6cb,
title = "Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF",
abstract = "The vertebrate transcription factors TCF (T cell factor) and LEF (lymphocyte enhancer binding factor) interact with β-catenin and are hypothesized to mediate Wingless/Wnt signaling. We have cloned a maternally expressed Drosophila TCF family member, dTCF- dTCF binds a canonical TCF DNA motif and interacts with the β-catenin homolog Armadillo. Previous studies have identified two regions in Armadillo required for Wingless signaling. One of these interacts with dTCF, while the other constitutes a transactivation domain. Mutations in dTCF and expression of a dominant-negative dTCF transgene cause a segment polarity phenotype and affect expression of the Wingless target genes engrailed and Ultrabithorax. Epistasis analysis positions dTCF downstream of armadillo. The Armadillo-dTCF complex mediates Wingless signaling as a bipartite transcription factor.",
author = "{Van de Wetering}, Marc and Robert Cavallo and Dennis Dooijes and {Van Beest}, Moniek and {Van Es}, Johan and Joseph Loureiro and Arne Ypma and Deborah Hursh and Tamara Jones and Amy Bejsovec and Mark Peifer and Mark Mortin and Hans Clevers",
note = "Funding Information: Correspondence should be addressed to M. P., M. M., or H. C. We thank J. Locke and R. Holmgren for fly strains, DNA samples, and valuable discussions; J. Sekelsky, S. Hawley, L. Wallrath, S. Elgin, and the Bloomington Drosophila Stock Center for stocks; M. Bienz for communication of unpublished results; W. Birchmeier, J. Hirsh, J. Kennison, R. Dubreuil, J. Bos, and the members of the Destree, Clevers, and Peifer laboratories for helpful discussions; and J. Shields and C. A. McCormick for technical assistance. R. C. was supported by National Institutes of Health (NIH) training grant GM07092. This work was supported by PIONIER and Program grants from NWO-GMW to H. C., by NIH grant GM47857 to M. P., and by National Science Foundation grant 96–00539 to A. B.",
year = "1997",
month = mar,
day = "21",
doi = "10.1016/S0092-8674(00)81925-X",
language = "English",
volume = "88",
pages = "789--799",
journal = "Cell",
issn = "0092-8674",
number = "6",
}