Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1

Kornelius Kerl; Natalia Moreno; Till Holsten; Julia Ahlfeld; Julius Mertins; Marc Hotfilder; Marcel Kool; Kerstin Bartelheim; Sabine Schleicher; Rupert Handgretinger; Ulrich Schüller; Michael Meisterernst; Michael C. Frühwald

doi:10.1002/ijc.28719

Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1

Kornelius Kerl, Natalia Moreno, Till Holsten, Julia Ahlfeld, Julius Mertins, Marc Hotfilder, Marcel Kool, Kerstin Bartelheim, Sabine Schleicher, Rupert Handgretinger, Ulrich Schüller, Michael Meisterernst, Michael C. Frühwald

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

42 Citaten (Scopus)

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Rhabdoid tumors are highly aggressive tumors occurring in infants and very young children. Despite multimodal and intensive therapy prognosis remains poor. Molecular analyses have uncovered several deregulated pathways, among them the CDK4/6-Rb-, the WNT- and the Sonic hedgehog (SHH) pathways. The SHH pathway is activated in rhabdoid tumors by GLI1 overexpression. Here, we demonstrate that arsenic trioxide (ATO) inhibits tumor cell growth of malignant rhabdoid tumors in vitro and in a mouse xenograft model by suppressing Gli1. Our data uncover ATO as a promising therapeutic approach to improve prognosis for rhabdoid tumor patients.

Originele taal-2	Engels
Pagina's (van-tot)	989-995
Aantal pagina's	7
Tijdschrift	International Journal of Cancer
Volume	135
Nummer van het tijdschrift	4
DOI's	https://doi.org/10.1002/ijc.28719
Status	Gepubliceerd - 15 aug. 2014
Extern gepubliceerd	Ja

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10.1002/ijc.28719

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Kerl, K., Moreno, N., Holsten, T., Ahlfeld, J., Mertins, J., Hotfilder, M., Kool, M., Bartelheim, K., Schleicher, S., Handgretinger, R., Schüller, U., Meisterernst, M., & Frühwald, M. C. (2014). Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1. International Journal of Cancer, 135(4), 989-995. https://doi.org/10.1002/ijc.28719

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title = "Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1",

abstract = "Rhabdoid tumors are highly aggressive tumors occurring in infants and very young children. Despite multimodal and intensive therapy prognosis remains poor. Molecular analyses have uncovered several deregulated pathways, among them the CDK4/6-Rb-, the WNT- and the Sonic hedgehog (SHH) pathways. The SHH pathway is activated in rhabdoid tumors by GLI1 overexpression. Here, we demonstrate that arsenic trioxide (ATO) inhibits tumor cell growth of malignant rhabdoid tumors in vitro and in a mouse xenograft model by suppressing Gli1. Our data uncover ATO as a promising therapeutic approach to improve prognosis for rhabdoid tumor patients.",

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Kerl, K, Moreno, N, Holsten, T, Ahlfeld, J, Mertins, J, Hotfilder, M, Kool, M, Bartelheim, K, Schleicher, S, Handgretinger, R, Schüller, U, Meisterernst, M & Frühwald, MC 2014, 'Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1', International Journal of Cancer, vol. 135, nr. 4, blz. 989-995. https://doi.org/10.1002/ijc.28719

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AU - Kerl, Kornelius

AU - Moreno, Natalia

AU - Holsten, Till

AU - Ahlfeld, Julia

AU - Mertins, Julius

AU - Hotfilder, Marc

AU - Kool, Marcel

AU - Bartelheim, Kerstin

AU - Schleicher, Sabine

AU - Handgretinger, Rupert

AU - Schüller, Ulrich

AU - Meisterernst, Michael

AU - Frühwald, Michael C.

PY - 2014/8/15

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N2 - Rhabdoid tumors are highly aggressive tumors occurring in infants and very young children. Despite multimodal and intensive therapy prognosis remains poor. Molecular analyses have uncovered several deregulated pathways, among them the CDK4/6-Rb-, the WNT- and the Sonic hedgehog (SHH) pathways. The SHH pathway is activated in rhabdoid tumors by GLI1 overexpression. Here, we demonstrate that arsenic trioxide (ATO) inhibits tumor cell growth of malignant rhabdoid tumors in vitro and in a mouse xenograft model by suppressing Gli1. Our data uncover ATO as a promising therapeutic approach to improve prognosis for rhabdoid tumor patients.

AB - Rhabdoid tumors are highly aggressive tumors occurring in infants and very young children. Despite multimodal and intensive therapy prognosis remains poor. Molecular analyses have uncovered several deregulated pathways, among them the CDK4/6-Rb-, the WNT- and the Sonic hedgehog (SHH) pathways. The SHH pathway is activated in rhabdoid tumors by GLI1 overexpression. Here, we demonstrate that arsenic trioxide (ATO) inhibits tumor cell growth of malignant rhabdoid tumors in vitro and in a mouse xenograft model by suppressing Gli1. Our data uncover ATO as a promising therapeutic approach to improve prognosis for rhabdoid tumor patients.

KW - arsenic trioxide

KW - Gli1

KW - rhabdoid tumors

KW - Sonic hedgehog

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Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1

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