Asparaginase inhibits the lectin pathway of complement activation

M. P. Keizer, C. Aarts, A. M. Kamp, H. N. Caron, M. D. van de Wetering, D. Wouters, T. W. Kuijpers

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

3 Citaten (Scopus)


Oncological treatment has been associated with an increased risk of infection, most often related to therapy-induced pancytopenia. However, limited research has been conducted on the effect of oncological therapy on the complement system, being part of the non-cellular innate immune system. This became the rationale for an observational clinical study (C2012) in which we have investigated the prevalence of transient complement defects. Once we had observed such defects, a correlation of the complement defects to specific clinical parameters or to specific therapeutic regimens was investigated. A prominent defect observed in C2012 was the inhibition of the lectin pathway (LP) of complement activation during the treatment of acute lymphoblastic leukemia (ALL), which we could directly associate to the use of asparaginase (ASNase). Ex-vivo experiments confirmed a direct dose-dependent inhibitory effect of ASNase on the LP functionality.

Originele taal-2Engels
Pagina's (van-tot)189-192
Aantal pagina's4
TijdschriftMolecular Immunology
StatusGepubliceerd - jan. 2018
Extern gepubliceerdJa


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