Assessment of drug-induced immunotoxicity in animal models

Femke van Wijk; Stefan Nierkens

doi:10.1016/j.ddtec.2006.03.003

Assessment of drug-induced immunotoxicity in animal models

Femke van Wijk, Stefan Nierkens

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › peer review

10 Citaten (Scopus)

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With the growing understanding that drugs might induce immune-mediated adverse reactions in patients, immunotoxicity testing of new pharmaceuticals has become an important topic in drug development. The nonclinical assessment of unexpected immune suppression is based on relatively well-standardized and validated assays and animal models. For the evaluation of direct immune stimulation few animal models are available, whilst the development of animal models to assess drug-induced hypersensitivity and in particular autoimmunity is in its infancy.

Originele taal-2	Engels
Pagina's (van-tot)	103-109
Aantal pagina's	7
Tijdschrift	Drug Discovery Today: Technologies
Volume	3
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1016/j.ddtec.2006.03.003
Status	Gepubliceerd - 2006
Extern gepubliceerd	Ja

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title = "Assessment of drug-induced immunotoxicity in animal models",

abstract = "With the growing understanding that drugs might induce immune-mediated adverse reactions in patients, immunotoxicity testing of new pharmaceuticals has become an important topic in drug development. The nonclinical assessment of unexpected immune suppression is based on relatively well-standardized and validated assays and animal models. For the evaluation of direct immune stimulation few animal models are available, whilst the development of animal models to assess drug-induced hypersensitivity and in particular autoimmunity is in its infancy.",

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AU - Nierkens, Stefan

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AB - With the growing understanding that drugs might induce immune-mediated adverse reactions in patients, immunotoxicity testing of new pharmaceuticals has become an important topic in drug development. The nonclinical assessment of unexpected immune suppression is based on relatively well-standardized and validated assays and animal models. For the evaluation of direct immune stimulation few animal models are available, whilst the development of animal models to assess drug-induced hypersensitivity and in particular autoimmunity is in its infancy.

UR - https://www.scopus.com/pages/publications/33646010909

U2 - 10.1016/j.ddtec.2006.03.003

DO - 10.1016/j.ddtec.2006.03.003

M3 - Review article

AN - SCOPUS:33646010909

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VL - 3

SP - 103

EP - 109

JO - Drug Discovery Today: Technologies

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IS - 1

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Assessment of drug-induced immunotoxicity in animal models

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