Assessment of the role of neutrophils on the antitumor effect of TNFα in an in vivo isolated limb perfusion model sarcoma-bearing brown Norway rats

E. R. Manusama; P. T.G.A. Nooijen; J. Stavast; J. H.W. De Wilt; R. L. Marquet; A. M.M. Eggermont

doi:10.1006/jsre.1997.5256

Assessment of the role of neutrophils on the antitumor effect of TNFα in an in vivo isolated limb perfusion model sarcoma-bearing brown Norway rats

E. R. Manusama, P. T.G.A. Nooijen, J. Stavast, J. H.W. De Wilt, R. L. Marquet, A. M.M. Eggermont

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

21 Citaten (Scopus)

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Introduction. Isolated limb perfusion (ILP) with TNFα in combination with melphalan and IFNγ/has resulted in an immediate and dramatic tumor response in patients. Such an effect was also noted following ILP in a rat sarcoma model. This model enables us to investigate several factors responsible for the TNFα-induced tumor responses. We applied total body irradiation (TBI) to reduce white blood cell count, to investigate the contribution of leukocytes to the antitumor effect of TNFα.

Originele taal-2	Engels
Pagina's (van-tot)	169-175
Aantal pagina's	7
Tijdschrift	Journal of Surgical Research
Volume	78
Nummer van het tijdschrift	2
DOI's	https://doi.org/10.1006/jsre.1997.5256
Status	Gepubliceerd - aug. 1998
Extern gepubliceerd	Ja

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10.1006/jsre.1997.5256

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title = "Assessment of the role of neutrophils on the antitumor effect of TNFα in an in vivo isolated limb perfusion model sarcoma-bearing brown Norway rats",

abstract = "Introduction. Isolated limb perfusion (ILP) with TNFα in combination with melphalan and IFNγ/has resulted in an immediate and dramatic tumor response in patients. Such an effect was also noted following ILP in a rat sarcoma model. This model enables us to investigate several factors responsible for the TNFα-induced tumor responses. We applied total body irradiation (TBI) to reduce white blood cell count, to investigate the contribution of leukocytes to the antitumor effect of TNFα.",

keywords = "Chemotherapy, Oncology",

author = "Manusama, {E. R.} and Nooijen, {P. T.G.A.} and J. Stavast and {De Wilt}, {J. H.W.} and Marquet, {R. L.} and Eggermont, {A. M.M.}",

note = "Funding Information: This work was {\textregistered}nanced in part by the Dutch Cancer Society (Grant DDHK 93-659). We acknowledge Boehringer Ingelheim GmbH for generously providing TNFα. We thank Mr. W. P. van Schalkwijk for performing the in vitro platelet aggregations experiments and Mr.",

year = "1998",

month = aug,

doi = "10.1006/jsre.1997.5256",

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volume = "78",

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T1 - Assessment of the role of neutrophils on the antitumor effect of TNFα in an in vivo isolated limb perfusion model sarcoma-bearing brown Norway rats

AU - Manusama, E. R.

AU - Nooijen, P. T.G.A.

AU - Stavast, J.

AU - De Wilt, J. H.W.

AU - Marquet, R. L.

AU - Eggermont, A. M.M.

N1 - Funding Information: This work was ®nanced in part by the Dutch Cancer Society (Grant DDHK 93-659). We acknowledge Boehringer Ingelheim GmbH for generously providing TNFα. We thank Mr. W. P. van Schalkwijk for performing the in vitro platelet aggregations experiments and Mr.

PY - 1998/8

Y1 - 1998/8

N2 - Introduction. Isolated limb perfusion (ILP) with TNFα in combination with melphalan and IFNγ/has resulted in an immediate and dramatic tumor response in patients. Such an effect was also noted following ILP in a rat sarcoma model. This model enables us to investigate several factors responsible for the TNFα-induced tumor responses. We applied total body irradiation (TBI) to reduce white blood cell count, to investigate the contribution of leukocytes to the antitumor effect of TNFα.

AB - Introduction. Isolated limb perfusion (ILP) with TNFα in combination with melphalan and IFNγ/has resulted in an immediate and dramatic tumor response in patients. Such an effect was also noted following ILP in a rat sarcoma model. This model enables us to investigate several factors responsible for the TNFα-induced tumor responses. We applied total body irradiation (TBI) to reduce white blood cell count, to investigate the contribution of leukocytes to the antitumor effect of TNFα.

KW - Chemotherapy

KW - Oncology

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DO - 10.1006/jsre.1997.5256

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JO - Journal of Surgical Research

JF - Journal of Surgical Research

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ER -

Assessment of the role of neutrophils on the antitumor effect of TNFα in an in vivo isolated limb perfusion model sarcoma-bearing brown Norway rats

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