@article{860f2b32f450407f8c057d0af7e93b3a,
title = "Assessment of the role of neutrophils on the antitumor effect of TNFα in an in vivo isolated limb perfusion model sarcoma-bearing brown Norway rats",
abstract = "Introduction. Isolated limb perfusion (ILP) with TNFα in combination with melphalan and IFNγ/has resulted in an immediate and dramatic tumor response in patients. Such an effect was also noted following ILP in a rat sarcoma model. This model enables us to investigate several factors responsible for the TNFα-induced tumor responses. We applied total body irradiation (TBI) to reduce white blood cell count, to investigate the contribution of leukocytes to the antitumor effect of TNFα.",
keywords = "Chemotherapy, Oncology",
author = "Manusama, \{E. R.\} and Nooijen, \{P. T.G.A.\} and J. Stavast and \{De Wilt\}, \{J. H.W.\} and Marquet, \{R. L.\} and Eggermont, \{A. M.M.\}",
note = "Funding Information: This work was {\textregistered}nanced in part by the Dutch Cancer Society (Grant DDHK 93-659). We acknowledge Boehringer Ingelheim GmbH for generously providing TNFα. We thank Mr. W. P. van Schalkwijk for performing the in vitro platelet aggregations experiments and Mr.",
year = "1998",
month = aug,
doi = "10.1006/jsre.1997.5256",
language = "English",
volume = "78",
pages = "169--175",
journal = "Journal of Surgical Research",
issn = "0022-4804",
publisher = "Academic Press Inc.",
number = "2",
}