Atypical teratoid/rhabdoid tumor arising in a malignant glioma

Barbara Bozzai; Martin Hasselblatt; Eszter Turányi; Michael C. Frühwald; Reiner Siebert; Susanne Bens; Reinhard Schneppenheim; Marcel Kool; Gábor Stelczer; Tibor Hortobágyi; Peter Hauser

doi:10.1002/pbc.26173

Atypical teratoid/rhabdoid tumor arising in a malignant glioma

Barbara Bozzai, Martin Hasselblatt, Eszter Turányi, Michael C. Frühwald, Reiner Siebert, Susanne Bens, Reinhard Schneppenheim, Marcel Kool, Gábor Stelczer, Tibor Hortobágyi, Peter Hauser

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

8 Citaten (Scopus)

Samenvatting

Atypical teratoid/rhabdoid tumor (AT/RT), a highly malignant brain tumor in young children, usually arises de novo and has only rarely been described as a secondary malignancy. Here, we present a case of a child with glioblastoma, who was treated postoperatively by a combination of temozolomide, irradiation, and bevacizumab. AT/RT was diagnosed as a secondary tumor, 2.5 years following primary diagnosis. The child died 13 months after the diagnosis of AT/RT. This case demonstrates that malignant gliomas may give rise to AT/RT. It also emphasizes the diagnostic value of a repeated tumor biopsy in the recurrence setting.

Originele taal-2	Engels
Pagina's (van-tot)	96-99
Aantal pagina's	4
Tijdschrift	Pediatric Blood and Cancer
Volume	64
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1002/pbc.26173
Status	Gepubliceerd - 1 jan. 2017
Extern gepubliceerd	Ja

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10.1002/pbc.26173

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title = "Atypical teratoid/rhabdoid tumor arising in a malignant glioma",

abstract = "Atypical teratoid/rhabdoid tumor (AT/RT), a highly malignant brain tumor in young children, usually arises de novo and has only rarely been described as a secondary malignancy. Here, we present a case of a child with glioblastoma, who was treated postoperatively by a combination of temozolomide, irradiation, and bevacizumab. AT/RT was diagnosed as a secondary tumor, 2.5 years following primary diagnosis. The child died 13 months after the diagnosis of AT/RT. This case demonstrates that malignant gliomas may give rise to AT/RT. It also emphasizes the diagnostic value of a repeated tumor biopsy in the recurrence setting.",

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AU - Bozzai, Barbara

AU - Hasselblatt, Martin

AU - Turányi, Eszter

AU - Frühwald, Michael C.

AU - Siebert, Reiner

AU - Bens, Susanne

AU - Schneppenheim, Reinhard

AU - Kool, Marcel

AU - Stelczer, Gábor

AU - Hortobágyi, Tibor

AU - Hauser, Peter

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N2 - Atypical teratoid/rhabdoid tumor (AT/RT), a highly malignant brain tumor in young children, usually arises de novo and has only rarely been described as a secondary malignancy. Here, we present a case of a child with glioblastoma, who was treated postoperatively by a combination of temozolomide, irradiation, and bevacizumab. AT/RT was diagnosed as a secondary tumor, 2.5 years following primary diagnosis. The child died 13 months after the diagnosis of AT/RT. This case demonstrates that malignant gliomas may give rise to AT/RT. It also emphasizes the diagnostic value of a repeated tumor biopsy in the recurrence setting.

AB - Atypical teratoid/rhabdoid tumor (AT/RT), a highly malignant brain tumor in young children, usually arises de novo and has only rarely been described as a secondary malignancy. Here, we present a case of a child with glioblastoma, who was treated postoperatively by a combination of temozolomide, irradiation, and bevacizumab. AT/RT was diagnosed as a secondary tumor, 2.5 years following primary diagnosis. The child died 13 months after the diagnosis of AT/RT. This case demonstrates that malignant gliomas may give rise to AT/RT. It also emphasizes the diagnostic value of a repeated tumor biopsy in the recurrence setting.

KW - atypical teratoid/rhabdoid tumor

KW - glioblastoma

KW - irradiation

KW - pleomorphic xanthoastrocytoma

KW - temozolomide

KW - therapy-induced secondary tumor

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Atypical teratoid/rhabdoid tumor arising in a malignant glioma

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