Behandeling van infantiele hemangiomen met propranolol: Goede resultaten en weinig bijwerkingen

Denise J.J. Hermans, Maarten J. Ottenhof, Marc H.W.A. Wijnen, Ingrid M. Van Beynum, Chantal M.A.M. Van Der Horst, Carine J.M. Van Der Vleuten

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

8 Citaten (Scopus)

Samenvatting

Infantile haemangiomas (IH) are the most commonly occurring benign tumours of infancy, which may lead to considerable morbidity, such as amblyopia, ulceration and airway obstruction, depending on localization. Until recently, treatment was difficult: high-dose systemic glucocorticoids had limited effect and serious side effects. In 2008, the effectiveness of the beta-blocker propranolol for infantile haemangiomas was discovered; by now there is extensive worldwide experience. Data from the literature and from our own patient cohort (n = 132) confirm the remarkable efficacy of propranolol in complicated IH, without significant adverse effects. Propranolol is most effective in the proliferation phase of IH in children under 6 months of age. Timely referral of patients with potentially function-threatening or life-changing IH to a specialised multidisciplinary centre is therefore essential. Pending controlled studies, propranolol appears to have become the first choice treatment in complicated IH.

Vertaalde titel van de bijdrageTreatment of infantile hemangiomas with propranolol: Good results and few side effects
Originele taal-2Nederlands
Pagina's (van-tot)1793-1802
Aantal pagina's10
TijdschriftNederlands tijdschrift voor geneeskunde
Volume155
Nummer van het tijdschrift40
StatusGepubliceerd - 8 okt. 2011
Extern gepubliceerdJa

Trefwoorden

  • Adrenergic beta-Antagonists/adverse effects
  • Child
  • Child, Preschool
  • Disease Progression
  • Hemangioma/drug therapy
  • Humans
  • Infant
  • Infant, Newborn
  • Propranolol/adverse effects
  • Treatment Outcome

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