Body mass index and annual increase of body mass index in long-term childhood cancer survivors; Relationship to treatment

Cornelia A.J. Brouwer, Jourik A. Gietema, Judith M. Vonk, W. J.E. Tissing, Hendrika M. Boezen, Nynke Zwart, Aleida Postma

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

23 Citaten (Scopus)


Purpose: Evaluation of body mass index (BMI) at final height (FH) and annual BMI increase in adult childhood cancer survivors (CCS) after treatment with anthracyclines, platinum, and/or radiotherapy. Methods: BMI (weight/height2) was calculated retrospectively from diagnosis until FH. The prevalence of underweight (BMI < 18.5 kg/m 2) and overweight (BMI ≥ 25 kg/m 2)/obesity (BMI ≥ 30 kg/m 2) at FH was compared with age-matched controls. The association between underweight/ overweight at FH and treatment was assessed by multivariate logistic regression. Annual BMI increase after treatment was assessed by multilevel analysis. Analyses were adjusted for age and underweight/overweight at diagnosis, and age at FH. Results: At FH the prevalence of overweight had not increased, while CCS experienced more underweight as compared to controls (14% vs. 4%, P < 0.001). Overweight at FH was associated with cranial/craniospinal radiotherapy (CRT; OR, 2.23; 95% CI, 1.17-4.26) and underweight at FH with anthracyclines > 300 mg/m 2 (OR, 2.84; 95% CI, 1.33-6.06). Annual BMI increase was +0.47 (0.34-0.60) kg/m 2/year. In CCS, the annual BMI increase was greater in those with CRT ≥ 30 Gy as compared with those with less or no CRT (+0.15 kg/m 2/year [0.04-0.25 kg/m 2/year], P = 0.008) and smaller in those with a higher cumulative anthracycline dose (-0.03 kg/m 2/year [-0.05 to -0.0005 kg/m 2/year] per 100 mg/m 2, P = 0.046). Conclusions: After treatment with anthracyclines, platinum, and/or radiotherapy, CRT-treated survivors have more overweight at FH, and a greater annual BMI increase, while anthracycline-treated survivors have more underweight at FH and a lower annual BMI increase.

Originele taal-2Engels
Pagina's (van-tot)311-318
Aantal pagina's8
TijdschriftSupportive Care in Cancer
Nummer van het tijdschrift2
StatusGepubliceerd - feb. 2012
Extern gepubliceerdJa


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