TY - JOUR
T1 - Cancer Core Europe
T2 - A European cancer research alliance realizing a research infrastructure with critical mass and programmatic approach to cure cancer in the 21st century
AU - Calvo, Fabien
AU - Apolone, Giovanni
AU - Baumann, Michael
AU - Caldas, Carlos
AU - Celis, Julio E.
AU - de Lorenzo, Franceso
AU - Ernberg, Ingemar
AU - Ringborg, Ulrik
AU - Rowell, John
AU - Tabernero, Josep
AU - Voest, Emile
AU - Eggermont, Alexander
N1 - Publisher Copyright:
© 2018
PY - 2018/11
Y1 - 2018/11
N2 - Translational cancer research covers the whole cancer research continuum from basic to preclinical to early clinical, late clinical and outcomes research. Basic-preclinical research is the “engine” for early clinical research bridging the early translational research gap. Cancer Core Europe has been created to construct a sustainable, high level, shared research infrastructure platform with research collaborations and taskforces (data sharing, clinical trials, genomics, immunotherapy, imaging, legal & ethical problems, and education & training) having representatives from all seven member centres, in a controlled expansion model. In parallel, a consortium of ten cancer prevention centres was established, Cancer Prevention Europe, to support the complete cancer prevention research continuum. Cancer Core Europe is launching at present the Basket of Baskets trial, which is the largest personalized cancer medicine trial effort in Europe. At present, Cancer Core Europe and Cancer Prevention Europe are in the process of integrating therapeutics and prevention strategies to address in partnership the increasing cancer problem. By offering innovative approaches for cancer research, links to the healthcare systems, development of quality-assured multidisciplinary cancer care, as well as the assessment of long-term outcomes, the infrastructure is expected to serve as a hub to connect with other centres in Europe as well as on other continents. In this manner Cancer Core Europe and Cancer Prevention Europe prepare to tackle the “Mission on Cancer” with infrastructure and proofs of concept for therapeutics and prevention, research for assessment of effectiveness, health economics and added value for patients and the healthcare systems.
AB - Translational cancer research covers the whole cancer research continuum from basic to preclinical to early clinical, late clinical and outcomes research. Basic-preclinical research is the “engine” for early clinical research bridging the early translational research gap. Cancer Core Europe has been created to construct a sustainable, high level, shared research infrastructure platform with research collaborations and taskforces (data sharing, clinical trials, genomics, immunotherapy, imaging, legal & ethical problems, and education & training) having representatives from all seven member centres, in a controlled expansion model. In parallel, a consortium of ten cancer prevention centres was established, Cancer Prevention Europe, to support the complete cancer prevention research continuum. Cancer Core Europe is launching at present the Basket of Baskets trial, which is the largest personalized cancer medicine trial effort in Europe. At present, Cancer Core Europe and Cancer Prevention Europe are in the process of integrating therapeutics and prevention strategies to address in partnership the increasing cancer problem. By offering innovative approaches for cancer research, links to the healthcare systems, development of quality-assured multidisciplinary cancer care, as well as the assessment of long-term outcomes, the infrastructure is expected to serve as a hub to connect with other centres in Europe as well as on other continents. In this manner Cancer Core Europe and Cancer Prevention Europe prepare to tackle the “Mission on Cancer” with infrastructure and proofs of concept for therapeutics and prevention, research for assessment of effectiveness, health economics and added value for patients and the healthcare systems.
KW - Alliance
KW - Cancer research
KW - Infrastructure
KW - Innovation
KW - Oncopolicy
UR - http://www.scopus.com/inward/record.url?scp=85053384612&partnerID=8YFLogxK
U2 - 10.1016/j.ejca.2018.08.023
DO - 10.1016/j.ejca.2018.08.023
M3 - Article
C2 - 30241002
AN - SCOPUS:85053384612
SN - 0959-8049
VL - 103
SP - 155
EP - 159
JO - European Journal of Cancer
JF - European Journal of Cancer
ER -